A two-sample bidirectional Mendelian randomization study on gut microbiota, dental caries, and toothache. [PDF]
Medicine (Baltimore)Zhang L, Zheng X, Xia J, Guo L, Yang S.
europepmc +1 more source
Movement Disorders, EarlyView.Abstract Background Long‐read sequencing and multi‐omic analytical frameworks are increasingly being adopted in rare disease diagnostics. However, clinical workflows comprehensively integrating these methodologies remain uncommon. Objective This study aimed to assess the potential and limitations of integrating long‐read genomic, transcriptomic, and ...
Ugo Sorrentino +23 more
wiley +1 more source
Immune cell-mediated effects of plasma lipids on heart failure: A two-step, two-sample Mendelian randomization study. [PDF]
Medicine (Baltimore)Liu Z +11 more
europepmc +1 more source
Causal insights into how NAFLD progression drives abdominal aortic aneurysm: A bidirectional MR study integrating genetic and multi-omics profiling. [PDF]
Medicine (Baltimore)Xi R +6 more
europepmc +1 more source
Rare‐Variant Burden Analysis of Dystonia Genes in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Dystonia frequently coexists with Parkinson's disease (PD), yet the extent of genetic overlap remains insufficiently explored. Objective The aim was to examine whether rare variants in dystonia‐related genes are associated with PD or early‐onset PD (EOPD).
Sajanth Kanagasingam +4 more
wiley +1 more source
Genetically predicted N-acetylisoleucine levels mediate the association between PB/PC% lymphocyte and normal pressure hydrocephalus: A mediation Mendelian randomization study. [PDF]
Medicine (Baltimore)Liu C +5 more
europepmc +1 more source
Sickle Cell Disease: Historical Overview and Current Therapies
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Causal link between maternal PCOS and fetal/neonatal hemorrhagic and hematological disorders: A 2-sample MR study. [PDF]
Medicine (Baltimore)Yang C +9 more
europepmc +1 more source
Phenotypic Clues in Infantile‐Onset Parkinsonism‐Dystonia‐2: A Treatable Neurotransmitter Disorder
Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan +10 more
wiley +1 more source
Pediatric Discovery, EarlyView.Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang +7 more
wiley +1 more source