Results 201 to 210 of about 133,969 (268)

Causal effects of obesity on urolithiasis and the mediating role of inflammatory factors: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Chen J, Song C, Chen C, You M, Chen B.
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Causal relationship between intervertebral disc degeneration and neurological disorders: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Cao X.
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Causal Mediation of Immune Cells and Fatty Acids in Coronary Atherosclerosis: Insights From Mendelian Randomization Analysis. [PDF]

Hum Mutat
Zhang Y, Xu J, Deng Z, Long X, Liu J, Jiang L, Liu N, Zhang D, Zhou W, Zhu P.   +9 more
europepmc   +1 more source

The Gut Microbiome as a Therapeutic Target in Alopecia Areata: Not Yet Part of the Patient Treatment Plan

International Journal of Dermatology, EarlyView.
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen, Deema Abdel Hafeez, Nikhil Pai, Laurence Mainville, Shireen Dumont, Narachai Julanon, Romy Shenderey, Grace Xiong, Shahnawaz Towheed, Jeffrey Donovan   +9 more
wiley   +1 more source

The association between two common levels of apolipoprotein and chronic obstructive pulmonary disease: A Mendelian randomized study. [PDF]

Medicine (Baltimore)
Chen C, Sun Z, Zhong W, Zheng H, Zuo Z, Zhang X, Wang Y, Zhao W, Shen B.   +8 more
europepmc   +1 more source

The mechanism of Mendelian heredity

, 1915
openaire   +5 more sources

Iron Overload: Pathophysiology, Diagnosis and Monitoring

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil, Polyxeni Delaporta, Konstantinos Bistas, Antonis Kattamis   +3 more
wiley   +1 more source

Association of depression with keratitis: A bidirectional 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhang Y, Niu D, Chen M, Ji M, Zhang J, Zhou R.   +5 more
europepmc   +1 more source