Results 181 to 190 of about 184,242 (260)

Plasma Lipid Remodeling across Preclinical Burden, Disease Onset, and Early Motor Severity in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background and Objectives Huntington's disease (HD) evolves silently for years before motor onset, yet the systemic metabolic alterations accompanying cumulative exposure to mutant huntingtin and disease progression remain poorly understood.
Mohamed Bendimerad, Dominique Bonneau, Clarisse Scherer‐Gagou, Adriana Prundean, Karim Chikh, Oriane Vitalis, Audrey Olivier, Odile Blanchet, Judith Nzoughet‐Kouassi, Christophe Verny, Pascal Reynier, Juan Manuel Chao de la Barca   +11 more
wiley   +1 more source

Integrative analysis prioritizes proteins associated with renal cell carcinoma and its risk factors. [PDF]

JNCI Cancer Spectr
Sajal IH, Song AJ, Brown KM, Machiela MJ, Kraft P, Chanock S, Purdue MP, Dutta D.   +7 more
europepmc   +1 more source

The bidirectional causal relationships of insomnia with eleven cancers: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Li J, Cheng L, Li F, Xu Y.
europepmc   +1 more source

Statin Exposure and Survival Outcomes in Amyotrophic Lateral Sclerosis in an Asian Cohort

Muscle &Nerve, EarlyView.
ABSTRACT Introduction Data from Asian cohorts on whether statin therapy affects amyotrophic lateral sclerosis (ALS) progression are limited. We examined whether statin exposure was associated with ALS disease duration or tracheostomy‐free survival in a multiethnic Asian ALS cohort.
Anushika Raheja, Kexin Ang, Bernett Lee, Seyed Ehsan Saffari, Eng King Tan, Crystal Jing Jing Yeo   +5 more
wiley   +1 more source

Association between hypertension and frozen shoulder: A bidirectional two-sample mendelian randomization study. [PDF]

Medicine (Baltimore)
Hua D, Chen Y, Wang L, Li N, Xu X.
europepmc   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Genetic Liability to Psychiatric Disorder and Risk of Musculoskeletal Diseases: A Bidirectional Mendelian Randomization Study. [PDF]

Actas Esp Psiquiatr
Luo X, Wu N, Wang Z, Ma J, Zhang X.
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Body mass index and type 2 diabetes liability in osteomyelitis and cellulitis: A cross-biobank Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu F, Luo K, Liu H.
europepmc   +1 more source

Levodopa and Melanoma: Practical Recommendations for Parkinson's Disease—International Parkinson and Movement Disorder Society Scientific Issues Committee Viewpoint

Movement Disorders Clinical Practice, EarlyView.
Giorgia Sciacca, Inas Elsayed, Santiago Perez‐Lloret, Tiago F. Outeiro, Vivek K. Unni, Jeffery H. Kordower, Daniela Berg, Lorraine V. Kalia, on behalf of the MDS Scientific Issues Committee, Jane Alty, Alexander Balck, Daniela Berg, Per Borghammer, Inas Elsayed, Yue Huang, Walaa Kamel Elsayed, Jeffrey Kordower, Alexander Lehn, Michele Matarazzo, Tiago Mestre, Tiago Outeiro, Gian Pal, Santiago Perez Lloret, Roopa Rajan, Sephira Ryman, Giorgia Sciacca, Per Svenningsson, Lorraine Kalia   +27 more
wiley   +1 more source