Results 141 to 150 of about 4,310,301 (302)

Moderate hyperuricaemia ameliorated kidney damage in a low‐renin model of experimental renal insufficiency

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 21-32, January 2023., 2023
Abstract Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricaemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham operation, the rats were allocated
Venla Kurra, Arttu Eräranta, Timo Paavonen, Teemu Honkanen, Juhani Myllymäki, Asko Riutta, Ilkka Tikkanen, Päivi Lakkisto, Jukka Mustonen, Ilkka Pörsti   +9 more
wiley   +1 more source

Mendelian randomization

Nature Reviews Methods Primers, 2022
E. Sanderson, M. M. Glymour, M. Holmes, Hyunseung Kang, J. Morrison, M. Munafo, T. Palmer, C. Schooling, Chris Wallace, Qingyuan Zhao, G. Davey Smith   +10 more
semanticscholar   +1 more source

Bias in causal estimates from Mendelian randomization studies with weak instruments [PDF]

, 2011
Stephen Burgess, Simon G. Thompson
openalex   +1 more source

Exploring the Causal Relationship Between Immune Cells and Idiopathic Pulmonary Fibrosis: A Mendelian Randomization Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Immunophenotypes of immune cells associated with idiopathic pulmonary fibrosis analyzed by the IVW method. ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with a complex pathogenesis involving multiple immune cells.
Peng Gong, Yimin Lu, Xi Chai, Xiaobo Li
wiley   +1 more source

Genetic inference of orchid population dynamics on different‐aged lava flows in Costa Rica

Biotropica, Volume 55, Issue 1, Page 95-105, January 2023., 2023
Volcán Arenal lava flows represent natural, non‐anthropogenic habitat disturbance that permit precise knowledge of when these sites became available for colonization. By examining the levels and spatial distribution of genetic variation of five Epidendrum radicans populations growing on lava flows deposited in 1968 and 1992, we were able to infer ...
Dorset W. Trapnell, James L. Hamrick
wiley   +1 more source

Schizophrenia and Types of Stroke: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and ...
Shinya Nakada, Frederick K. Ho, Carlos Celis‐Morales, Jill P. Pell   +3 more
doaj   +1 more source

Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53 221 adults [PDF]

, 2011
Debbie A. Lawlor, Roger Harbord, Anne Tybjærg‐Hansen, Tom Palmer, Jeppe Zacho, Marianne Benn, Nicholas J. Timpson, George Davey Smith, Børge G. Nordestgaard   +8 more
openalex   +1 more source

A genetic instrument for Mendelian randomization of fibrinogen [PDF]

, 2012
Gie Ken‐Dror, Steve E. Humphries, Meena Kumari, Mika Kivimäki, Fotios Drenos   +4 more
openalex   +1 more source

The longitudinal effects of neonatal anthropometry on attention problems in males and females

JCPP Advances, EarlyView.
Previous studies have demonstrated sex differences in the relationship between neonatal anthropometry and increased attention problems. Our study demonstrates that the nature of this relationship ‐ quadratic versus linear ‐ varies according to the anthropometric measure used and that the impact of increasing age on these effects differ in males and ...
Lars Meinertz Byg, Carol Wang, Jonathan J. Hirst, Roger Smith, Craig Pennell   +4 more
wiley   +1 more source

Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).
Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan   +5 more
doaj   +1 more source