Results 141 to 150 of about 95,337 (328)

Reduced Serum Soluble L‐Selectin Levels but Not PCSK9 May Be Associated With Generalized Anxiety Disorder: A Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
The study included 88 generalized anxiety disorder (GAD) patients and 88 age and sex‐matched healthy controls (HCs). A psychiatrist confirmed the GAD diagnosis, assessed symptom severity using the GAD‐7 scale, and evaluated controls based on the DSM‐5 criteria.
Farzana Akter Munny, Abir Hasan Pranto, Shimanta Paul, Md. Aminul Haque, Rashna Sharmin, Sharifa Sultana, Md. Alamgir Hossain, Md. Rabiul Islam   +7 more
wiley   +1 more source

Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study

Hereditas
Objective To investigate the causal relationship between minerals and vitamins and acute and chronic tubulointerstitial nephritis by Mendelian randomization.
Xiaotan Pan, Zhiyan Guo, Yin Zheng, Cheng Su, Jiabo Chen   +4 more
doaj   +1 more source

Revealing the link between gut microbiota and brain tumor risk: a new perspective from Mendelian randomization

Frontiers in Cellular and Infection Microbiology
BackgroundRecent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used the Mendelian randomization study (MR) method to explore the potential causal link between gut ...
Jianyu Yang, Jietao Lu, Yuhan Dong, Youdong Wei, Michael Christian, Junmeng Huang, Haiyan Kuang, Du Cao   +7 more
doaj   +1 more source

Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates.

PLoS ONE, 2019
Methods have been developed for Mendelian randomization that can obtain consistent causal estimates under weaker assumptions than the standard instrumental variable assumptions.
Jessica M B Rees, Angela M Wood, Frank Dudbridge, Stephen Burgess   +3 more
doaj   +1 more source

Child height, health and human capital: evidence using genetic markers [PDF]

Height has long been recognised as associated with better outcomes: the question is whether this association is causal. We use children’s genetic variants as instrumental variables (IV) to deal with possible unobserved confounders and examine the effect ...
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core  

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study

Frontiers in Endocrinology
BackgroundAberrant lipid metabolism is intricately linked to the development of endometrial cancer, and statin lipid-lowering medications are regarded as promising adjunctive therapies for future management of this malignancy.
Zhehan Yang, Zhehan Yang, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Ming Zeng, Ming Zeng, Sichen Li, Sichen Li, Yao Long, Yao Long, Zhiyi Zhou, Chunyan Wang, Chunyan Wang   +14 more
doaj   +1 more source

Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a Mendelian Randomization study [PDF]

, 2019
Marios K. Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie Sudlow, Martin Dichgans   +5 more
openalex   +1 more source

Dose‐dependent association of systemic comorbidities with periodontitis severity: A large population cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley   +1 more source

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

AMB Express
We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers.
Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge   +8 more
doaj   +1 more source