Results 161 to 170 of about 45,355 (266)

Sleep and dementia: Assessing established dementia-related factors using multivariable Mendelian randomization. [PDF]

Alzheimers Dement
Guo Y, Wang R, Sindi S, Middleton LT, Kivipelto M.   +4 more
europepmc   +1 more source

The Gut Microbiome as a Therapeutic Target in Alopecia Areata: Not Yet Part of the Patient Treatment Plan

International Journal of Dermatology, EarlyView.
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen, Deema Abdel Hafeez, Nikhil Pai, Laurence Mainville, Shireen Dumont, Narachai Julanon, Romy Shenderey, Grace Xiong, Shahnawaz Towheed, Jeffrey Donovan   +9 more
wiley   +1 more source

Causal genes for osteoporosis: Mendelian randomization analysis with multilayer xQTL data. [PDF]

Medicine (Baltimore)
Yu F, Wan X, Qiu J.
europepmc   +1 more source

Estimation of Genetic Variance and Breeding Values for Infectious Disease Susceptibility From Simulated Longitudinal Data Using Generalized Linear Mixed Models Based on Transmission Dynamics

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Recent theoretical work shows that the potential of genetic selection to reduce the prevalence of infectious diseases is much larger than expected from classical quantitative genetic theory, due to indirect genetic effects that arise in the transmission process. However, to fully benefit from these indirect effects, we need to estimate genetic
A. D. Hulst, R. Pong‐Wong, A. Doeschl‐Wilson, M. C. M. De Jong, P. Bijma   +4 more
wiley   +1 more source

Prognostic biomarkers for lung adenocarcinoma based on Mendelian randomization analysis. [PDF]

J Int Med Res
Yang LR, Li TT, Teng ZW, Peng XH, Liu Y, Chen L, Fan J.   +6 more
europepmc   +1 more source

Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Finnish Ayrshire cattle belong to the Nordic Red breeds. The basis of selection in Nordic Red breeds shifted from traditional pedigree‐based breeding values to genomic breeding values between 2011 and 2014. Joint genetic evaluation and admixture among the Nordic Red breeds have led to the formation of a composite Nordic Red population ...
Katri Sarviaho, Minna Koivula, Terhi Iso‐Touru, Pekka Uimari, Katja Hänninen   +4 more
wiley   +1 more source

Bidirectional and Multivariable Mendelian Randomization Study of PCOS and VTE. [PDF]

Int J Womens Health
You L, Cui H, Zhao F, Huang H, Xu W.
europepmc   +1 more source

Single‐Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. It reduces quality of life and increases the risk of complications such as stroke. Although progress has been made in understanding its pathogenesis, the key cellular subtypes and therapeutic targets remain unclear. Methods We applied single‐cell transcriptomics
Xiangpeng Chen, Hongquan Chen, Shiguang Xu, Shumin Wang, Huishan Wang, Hao Meng   +5 more
wiley   +1 more source

Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study. [PDF]

Sci Rep
Wang JL, Zhao Q, Zheng R, Fang Y, Cao J, Zhang BR.   +5 more
europepmc   +1 more source

Student–teacher relationships as a mediator of children's education‐linked genetics: results from the Norwegian Mother, Father and Child Cohort Study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Genetic differences are robustly associated with educational outcomes, but how they become linked is poorly understood. A plausible hypothesis, yet to be thoroughly empirically tested, is that the school environment mediates the association. Methods Using structural equation models, we tested whether the student–teacher relationship at age 5
Chloe Austerberry, Elizabeth C. Corfield, Alexandra Havdahl, Dinka Smajlagic, Ragnhild Eek Brandlistuen, Mari Vaage Wang, Laurel Fish, Marialivia Bernardi, Jessica van de Grint‐Stoop, Mona Bekkhus, Pasco Fearon   +10 more
wiley   +1 more source