Results 161 to 170 of about 143,068 (301)

Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies

Med Research, EarlyView.
ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data formats, challenges in multi‐omics integration, and ...
Xu Zhang, Kailai Li, Yasi Zhang, Cenwen Liu, Shunyi Huang, Yingzhao Jin, Yugeng Gao, Quan Cheng, Yunyun Mei   +8 more
wiley   +1 more source

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

Advancing Artificial Intelligence in Myopia Management: From Predicting Progression to Supporting Clinical Decisions

Med Research, EarlyView.
The AI‐enabled multimodal framework for whole‐life myopia management. Graphical abstract illustrates the transition of myopia care from premyopia to myopia, high myopia, and pathologic myopia. Multimodal data, including demographic and refractive information, genetic, behavioral and environmental factors, ophthalmic imaging, and omics profiles, can be ...
Zewei Zhang, Yun Wang, Lifei Zhang, Dongmei Chen, Weijie Zhang, Fang Li, Jibo Zhou   +6 more
wiley   +1 more source

Investigating the Impact of Gut Microbiota on Gout Through Mendelian Randomization [PDF]

Chaoqun Tang,1 Lei Li,2 Xin Jin,2 Jinfeng Wang,2 Debao Zou,2 Yan Hou,2 Xin Yu,2 Zhizhou Wang,2 Hongjiang Jiang1,2 1The First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, People’s Republic of China; 2Department of ...
Jin X, Jiang H, Tang C, Zou D, Li L, Wang J, Hou Y, Wang Z, Yu X   +8 more
core  

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source

Bidirectional Two-Sample Mendelian Randomization Analysis Reveals Causal Associations Between Modifiable Risk Factors and Fibromyalgia [PDF]

Wei Zu,1,* Shaojiong Zhou,2,* Tao Du,1 Chenyanwen Zhu,3 Siyue Nie,4 Hongwei Zhu1 1Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Neurology & Innovation ...
Nie S, Du T, Zhou S, Zu W, Zhu H, Zhu C
core  

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Child height, health and human capital: evidence using genetic markers [PDF]

Height has long been recognised as associated with better outcomes: the question is whether this association is causal. We use children’s genetic variants as instrumental variables (IV) to deal with possible unobserved confounders and examine the effect ...
Frank Windmeijer, Carol Propper, Stephanie von Hinke Kessler Scholder, George Davey Smith, Debbie A. Lawlor   +4 more
core  

Methomyl resistance in Dalbulus maidis (Hemiptera: Cicadellidae): selection, inheritance and multiple‐resistance

Pest Management Science, EarlyView.
The inheritance of methomyl resistance in Dalbulus maidis is autosomal, incompletely dominant and polygenic. No cross‐resistance was found between methomyl and chlorfenapyr, cyantraniliprole and isocycloseram. Abstract BACKGROUND Acetylcholinesterase (AChE) inhibitor insecticides have been important tools for the management of Dalbulus maidis in Brazil;
Matheus Gerage Sacilotto, Gabriel Silva Dias, Mariana Yuki Iuanami, Celso Omoto   +3 more
wiley   +1 more source