Results 141 to 150 of about 143,068 (301)

Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study

Hereditas
Objective To investigate the causal relationship between minerals and vitamins and acute and chronic tubulointerstitial nephritis by Mendelian randomization.
Xiaotan Pan, Zhiyan Guo, Yin Zheng, Cheng Su, Jiabo Chen   +4 more
doaj   +1 more source

The role of rare copy number variants in early‐onset depression

JCPP Advances, EarlyView.
Abstract Background Depression is a highly heterogeneous condition. Depression with an onset in childhood and early adolescence has a worse clinical course, is more heritable, and shows a lower genetic correlation with other depression subtypes, than does later‐onset depression.
Charlotte A. Dennison, Ida Sønderby, Miguel Garcia‐Argibay, Victoria Powell, Amy Shakeshaft, Lucy Riglin, Elliott Rees, Michael O’Donovan, Henrik Larsson, Ole Andreassen, Alexandra Havdahl, Joanna Martin, Anita Thapar   +12 more
wiley   +1 more source

Revealing the link between gut microbiota and brain tumor risk: a new perspective from Mendelian randomization

Frontiers in Cellular and Infection Microbiology
BackgroundRecent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used the Mendelian randomization study (MR) method to explore the potential causal link between gut ...
Jianyu Yang, Jietao Lu, Yuhan Dong, Youdong Wei, Michael Christian, Junmeng Huang, Haiyan Kuang, Du Cao   +7 more
doaj   +1 more source

Integrating Mendelian Randomization and Machine Learning to Identify Hypoxia-Related Diagnostic Biomarkers and Causal Relationship in COPD [PDF]

Wenhui Fu, Yangli Liu, Renjie Li, Haiying Jin Department of Respiratory Medicine, Jinyun People’s Hospital, Lishui, Zhejiang, 321400, People’s Republic of ChinaCorrespondence: Haiying Jin, Department of Respiratory Medicine, Jinyun People’s Hospital, No.
Liu Y, Jin H, Fu W, Li R
core  

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Gut microbiota, blood metabolites, & pan-cancer: a bidirectional Mendelian randomization & mediation analysis

AMB Express
We propose using Mendelian randomization analysis on GWAS data and MetaboAnalyst to model gut microbiota, metabolic pathways, blood metabolites, and cancer risk. We examined 473 gut microbiota, 205 pathways, 1400 metabolites, and 8 cancers.
Biqing Luan, Yang Yang, Qizhi Yang, Zhiqiang Li, Zhihui Xu, Yaqin Chen, Meiting Wang, Wenlin Chen, Fei Ge   +8 more
doaj   +1 more source

Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study

Frontiers in Endocrinology
BackgroundAberrant lipid metabolism is intricately linked to the development of endometrial cancer, and statin lipid-lowering medications are regarded as promising adjunctive therapies for future management of this malignancy.
Zhehan Yang, Zhehan Yang, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Ming Zeng, Ming Zeng, Sichen Li, Sichen Li, Yao Long, Yao Long, Zhiyi Zhou, Chunyan Wang, Chunyan Wang   +14 more
doaj   +1 more source

Effects of Obstructive Sleep Apnea on Personality and Temperament: A Cohort and Mendelian Randomization Study. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Objective Obstructive sleep apnea (OSA) is associated with neurocognitive impairment, but its causal relationship with personality traits remains poorly understood. This study investigates the association and causality between OSA and personality using both cohort and genetic data.
Liao JH, Shi YH, Xu XP, Li YR, Han DM.
europepmc   +2 more sources

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source

E-Values for Mendelian Randomization

Epidemiology, 2020
Swanson, Sonja, VanderWeele, TJ
openaire   +3 more sources