Results 181 to 190 of about 81,479 (293)

Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes mellitus (T2DM) has been inversely associated with prostate cancer (PrCa) risk. However, it remains unclear whether a polygenic risk score (PRS) for PrCa can effectively stratify risk among men with T2DM. The primary objective of this study was to assess whether a PrCa PRS predicts PrCa risk independently of T2DM status ...
Guk Jin Lee, Sang‐Hyuk Jung, Jonghyun Lee, Ki Won Moon, Penn Medicine Biobank, Daniel J. Rader, Marylyn D. Ritchie, JoEllen Weaver, Nawar Naseer, Giorgio Sirugo, Afiya Poindexter, Yi‐An Ko, Kyle P. Nerz, Meghan Livingstone, Fred Vadivieso, Stephanie DerOhannessian, Teo Tran, Julia Stephanowski, Salma Santos, Ned Haubein, Joseph Dunn, Colleen Morse Kripke, Marjorie Risman, Renae Judy, Colin Wollack, Anurag Verma, Shefali S. Verma, Scott Damrauer, Yuki Bradford, Scott Dudek, Theodore Drivas, Jae‐Seung Yun, Dokyoon Kim   +32 more
wiley   +1 more source

Oral Microbiome and Constipation: A Causal Link Revealed by Mendelian Randomization. [PDF]

JGH Open
Zhao Z, Ling J, Chen J.
europepmc   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li, Jing Sun, Jianhui Zhao, Fangyuan Jiang, Meng Zhang, Hao Wu, Shuai Yuan, Xue Li, Juan Lu, Christos S. Mantzoros   +9 more
wiley   +1 more source

Mendelian randomization: prospects, potentials, and limitations [PDF]

International Journal of Epidemiology, 2004
George Davey, Smith, Shah, Ebrahim
openaire   +2 more sources

The impact of different intensities of physical activity on aging: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Li H, Guo W, Nie Q, Tang Q, Li H.
europepmc   +1 more source

Higher Body Mass Index Is a Causal Risk Factor for Skin Infections: A Mendelian Randomisation Study Using UK Biobank and FinnGen

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Infections remain a leading cause of mortality and morbidity globally. We aimed to evaluate the potential causal role of higher BMI on common bacterial, viral and fungal infections using Mendelian randomisation (MR). Material and Methods In UK Biobank (N = 502 131, N = 230 542 with linked GP records), we tested observational associations ...
Rhian Hopkins, Ethan de Villiers, Michael N. Weedon, Beverley M. Shields, John M. Dennis, Andrew P. McGovern, Harry D. Green   +6 more
wiley   +1 more source

Association of endometriosis with hematuria markers: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Huang SP, Zhang ZC, Li J, Li LY, Ding WJ, Xie CY, Zhang YT, Li WH.   +7 more
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Mendelian randomization analyses

Mendelian randomization analyses will be conducted, using either single variants or polygenic risk scores robustly associated with lifestyle behaviours, to identify causal pathways between lifestyle behaviours during pregnancy and offspring outcomes.
openaire   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source