Results 231 to 240 of about 4,310,301 (302)

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies [PDF]

, 2016
Daniel I. Swerdlow, Karoline Kuchenbaecker, Sonia Shah, Reecha Sofat, Michael V. Holmes, Jon White, Jennifer S. Mindell, Mika Kivimäki, Eric J. Brunner, John C. Whittaker, Juan P. Casas, Aroon D. Hingorani   +11 more
openalex   +1 more source

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Correction: Kidney damage on fertility and pregnancy: A Mendelian randomization. [PDF]

PLoS One
Ren J, Huang Q, Nie X, Tong X, Yao Q, Zhou G.   +5 more
europepmc   +1 more source

Beyond Mendelian randomization: how to interpret evidence of shared genetic predictors

, 2015
Stephen Burgess, Adam S. Butterworth, John R. Thompson   +2 more
openalex   +1 more source

A causal association between osteoporosis and postural instability: a Mendelian randomization study. [PDF]

Sci Rep
Zhu K, An Z, Li Y, Zhang Q, Zhang F, Zhao R, Yu H, Yao Q.   +7 more
europepmc   +1 more source

Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study [PDF]

, 2016
Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L. Relton, So-Youn Shin, Min‐Jeong Shin   +6 more
openalex   +1 more source

Mendelian randomization of serum micronutrients and osteoarthritis risk: focus on zinc. [PDF]

Nutr J
Zeng W, Hong E, Ye W, Ma L, Cun D, Huang F, Jiang Z.   +6 more
europepmc   +1 more source

The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study [PDF]

, 2016
Robert Carreras‐Torres, Philip Haycock, Caroline L. Relton, Richard M. Martin, George Davey Smith, Peter Kraft, Chi Gao, Shelley S. Tworoger, Loı̈c Le Marchand, Lynne R. Wilkens, Sungshim L. Park, Christopher A. Haiman, John K. Field, Michael Davies, Michael W. Marcus, Geoffrey Liu, Neil E. Caporaso, David C. Christiani, Yongyue Wei, Chu Chen, Jennifer A. Doherty, Gianluca Severi, Gary E. Goodman, Rayjean J. Hung, Christopher I. Amos, James McKay, Mattias Johansson, Paul Brennan   +27 more
openalex   +1 more source

Reverse transcriptase inhibitors in Aicardi–Goutières syndrome: A crossover clinical trial

Developmental Medicine &Child Neurology, EarlyView.
Viral nucleic acid recognition induces a physiological type I interferon mediated innate immune response. In some cases of Aicardi‐Goutières syndrome, this same response is proposed to be triggered by self‐derived nucleic acid generated through reverse transcription. Here, reverse transcriptase inhibitors were assessed in such cases.
Yanick J. Crow, Tracy A. Briggs, Despina Eleftheriou, Amitav Parida, Claire Battison, Annabel Giddings, Titouan Kennel, Richard A. Parker, AGS‐RTIs Study Group, Aimee Donald, Paddy Mcmaster, Jay Shetty, Katherine Jack, Alan J Quigley, Alice Burleigh, Felice D’Arco, Cheryl Hemingway, Ying Hong, Elena Moraitis, Fiona Price‐Kuehne, Annapurna Sudarsanam, Evangeline Wassmer, Katie Livingstone, Fraser JH Sutherland, Marie‐Thérèse El‐Daher, John Norrie, Hannah Ensor, Alison F Munro, Lee Murphy, Alan Maclean, Katy R Reid, Deborah Forbes, Vincent Bondet, Darragh Duffy, David PJ Hunt, Gillian I Rice   +35 more
wiley   +1 more source

The causal effect of glaucoma and diabetic retinopathy: a Mendelian randomization study. [PDF]

Diabetol Metab Syndr
Chen S, Lin M, Hong Y.
europepmc   +1 more source