Results 241 to 250 of about 81,479 (293)

BioWinfordMR: an online platform for comprehensive Mendelian randomization analysis. [PDF]

Front Immunol
Wang Y, Wu T, Lu X, Wang X, Xue W.
europepmc   +1 more source

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source

Personality disorders and cardiometabolic diseases: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yang W, Yang Z, Xi J, Bian C, Cheng Z.
europepmc   +1 more source

Dairy Intake and Type 2 Diabetes Mellitus in Iranian Older Adults: Insights From the Baseline Phase of the Birjand Longitudinal Aging Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 1348 Iranian adults aged ≥ 60 years in the BLAS baseline, total dairy intake showed no clear association with prevalent T2DM (adjusted OR: 1.42, p = 0.05). Higher yogurt (OR: 1.48–1.54) and cheese (OR: 1.44) intakes were linked to greater odds, whereas milk was not.
Mahboubeh Darabi, Amirmohammad Tajik, Mehraneh Movahedi Aliabadi, Zeinab Shakeri, Maryam Mohammadi, Hossein Fakhrzadeh, Mitra Moudi, Masoumeh Khorashadizadeh, Mehdi Varmaghani, Farshad Sharifi   +9 more
wiley   +1 more source

Causal effect of obesity on cataract and mediating roles of metabolites: a Mendelian randomization study. [PDF]

Int J Ophthalmol
Li C, Wang JM, Yang WH.
europepmc   +1 more source

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source