Results 261 to 270 of about 81,479 (293)

Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. [PDF]

Nat Aging
Taylor-Bateman V, Bothongo P, Walker V, Kehoe PG, Nordestgaard LT, Ben-Shlomo Y, Davies NM, Williams DM, Anderson EL.   +8 more
europepmc   +1 more source

Application of Mendelian randomization to appraise causality in relationships between the gut microbiome and cancer

Dawes A, Hatcher C, McKinlay A, Wade K.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Mendelian Randomization

JAMA, 2017
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Connor A, Emdin, Amit V, Khera, Sekar, Kathiresan   +2 more
exaly   +6 more sources

Mendelian randomization for nephrologists

Kidney International, 2023
Confounding is a major limitation of observational studies. Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data.
Ellen Dobrijevic, Anita van Zwieten, Krzysztof Kiryluk, Andrew J. Grant, Germaine Wong, Armando Teixeira-Pinto   +5 more
openaire   +2 more sources

Mendelian Randomization

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire   +2 more sources

Polygenic Mendelian Randomization

Cold Spring Harbor Perspectives in Medicine, 2020
Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR.
openaire   +2 more sources

Mendelian Randomization Dictionary

2019
pdf of Lawlor DA, Wade K, et al. A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization ...
openaire   +1 more source