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Mendelian randomization for nephrologists
Kidney International, 2023Confounding is a major limitation of observational studies. Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data.
Ellen Dobrijevic +5 more
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JAMA, 2017
Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Sandeep, Grover +3 more
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Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may be attributed to our inability to randomize the exposure variable in observational studies. Mendelian randomization (MR) is one approach to overcome confounding.
Sandeep, Grover +3 more
openaire +4 more sources
Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
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Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease. Taking advantage of the fact that genetic variation is randomized among children from the same parents, it allows genetic variants known to influence ...
openaire +2 more sources
Polygenic Mendelian Randomization
Cold Spring Harbor Perspectives in Medicine, 2020Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR.
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Understanding Mendelian Randomization
Clinical Spine SurgeryMendelian randomization (MR) is a statistical method that is rising in popularity. Although randomized controlled trials (RCTs) remain the gold standard in terms of inferring causality, they are not always feasible due to time, ethical, and resource constraints.
Garrison P. Bentz, Mark J. Lambrechts
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Mendelian Randomization for Dermatology Research
JAMA DermatologyThis JAMA Network Insight describes the use of mendelian randomization, including key assumptions that must be met, in dermatology research.
Gary, Hettinger +2 more
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Mendelian Randomization Dictionary
2019pdf of Lawlor DA, Wade K, et al. A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization ...
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Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hypertension, 2023Hillary Hosier +2 more
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