Results 91 to 100 of about 18,346 (199)
Advanced ScienceFOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional regulation of Foxg1 expression remains unclear.
Kai Zhuang +16 more
doaj +1 more source
American journal of cancer research, 2013 Menin acts as contextual a tumor suppressor and a tumor promoter, partly via epigenetic regulation of gene transcription. While menin is phosphorylated, it remains unclear whether wild type menin has other post-translational modifications. Here, we report that menin is SUMOylated by SUMO1 in vivo and in vitro, and the SUMOylation is reduced by a SUMO ...
Zi-Jie, Feng +4 more
openaire +1 more source
Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1
, 2011 Menin is the ubiquitously expressed nuclear protein product of the MEN1 gene, which interacts with PKB/Akt in the cytoplasm to inhibit its activity. This study describes a novel insulin-dependent mechanism of menin regulation and interaction with other ...
Sadeesh Ramakrishnan +5 more
core +1 more source
Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer
Cell Death and DiseaseLysosome-mediated autophagy (including mitophagy) is crucial for cell survival and homeostasis. Although the mechanisms of lysosome activation during stress are well recognized, the epigenetic regulation of lysosomal gene expression remains largely ...
Jun-Bo Yuan +8 more
doaj +1 more source
BloodAbstract Menin inhibitors that disrupt the menin-MLL interaction hold promise for treating specific acute myeloid leukemia (AML) subtypes, including those with KMT2A rearrangements (KMT2A-r), yet resistance remains a challenge. Here, through systematic chromatin-focused CRISPR screens, along with genetic, epigenetic,
Xinyue Zhou +13 more
openaire +2 more sources
, 2012 Correlation between changes in gene expression and changes in H3K4me3 in menin-null (KO) mESCs vs. wild-type (WT) mESCs (A), and menin-null PILECs vs. wild-type (WT) PILECs (B). Normalized average tag density surrounding the transcription start site (TSS)
Raja Jothi (31820) +1 more
core +1 more source
Glucose-Mediated Repression of Menin Promotes Pancreatic β-Cell Proliferation
, 2012 Menin, encoded by the Men1 gene, is responsible for β-cell tumor formation in patients with multiple endocrine neoplasia type 1. Recently, menin has been proven to negatively regulate β-cell proliferation during pregnancy.
Fengying Li +12 more
core +1 more source
Menin inhibitor MI-503 exhibits potent anti-cancer activity in osteosarcoma
Scientific ReportsSmall molecule Menin inhibitor recently has emerged as a new therapeutic by targeting the interaction of histone methyltransferase MLL1 (KMT2A) with Menin. MLL1 is associated with aggressive osteosarcoma (OS) in young adults.
Shen Tian +5 more
doaj +1 more source
Menin orchestrates corticogenesis via regulation of chromatin accessibility and activation of
Cell ReportsSummary: The development of the mammalian cerebral cortex is tightly regulated by epigenetic mechanisms. However, the role of epigenetic modifications in gene regulation and their impact on neocortical function remain poorly understood.
Shuzhong Wang +7 more
doaj +1 more source
Menin links estrogen receptor activation to histone H3K4 trimethylation
, 2006 The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4).
Höppener, Jo W M +5 more
core +1 more source