MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10-Mediated Angiogenesis. [PDF]
Cancer SciMEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Wei C +17 more
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An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment [PDF]
World Journal of Surgical OncologyThe menin protein, encoded by the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, serves as a critical regulator of cellular processes in human cancers.
Hao Li +6 more
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Hsa-miR-149-5p targets Men1 to inhibit the progression of gastric cancer through the HSPA6/JNK pathway [PDF]
Cancer Cell InternationalBackground The mechanisms underlying gastric cancer (GC) progression, including recurrence and metastasis, remain unclear. Studies have reported that microRNAs and Men1 are closely associated with multiple tumors, including GC.
Jin-xun Jiang +6 more
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Correction to "Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression". [PDF]
Adv Sci (Weinh)Advanced Science, Volume 13, Issue 52, 18 September 2026.
europepmc +2 more sources
Two novel multiple endocrine neoplasia type 1 variants caused thymic neuroendocrine tumor: a case report [PDF]
Hereditary Cancer in Clinical PracticeMultiple endocrine neoplasia type 1 (MEN1), or Wermer’s syndrome, is a rare autosomal dominant genetic disorder caused by MEN1 mutations, which rarely result in thymic tumors.
Zi Dai +8 more
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Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression [PDF]
Advanced SciencePancreatic neuroendocrine tumors (PanNETs) frequently exhibit loss or reduced expression of the tumor suppressor MEN1, a key regulator of tumor progression and DNA damage response (DDR).
Jianyun Jiang +11 more
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Frontiers in Endocrinology, 2023 BackgroundMultiple Endocrine Neoplasia type 1 is a rare genetic syndrome mainly caused by mutations of MEN1 gene and characterized by a combination of several endocrine and non-endocrine manifestations.
Laura Pierotti +12 more
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Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms
Endocrine Connections, 2022 Purpose: Mosaicism is a feature of several inherited tumor syndromes. Only a few cases of mosaicism have been described in multiple endocrine neoplasia type 1 (MEN1).
Arnaud Lagarde +13 more
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Mutational and large deletion study of genes implicated in hereditary forms of primary hyperparathyroidism and correlation with clinical features. [PDF]
PLoS ONE, 2017 The aim of this study was to carry out genetic screening of the MEN1, CDKN1B and AIP genes, both by direct sequencing of the coding region and multiplex ligation-dependent probe amplification (MLPA) assay in the largest monocentric series of Italian ...
Elena Pardi +13 more
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Frontiers in Endocrinology, 2020 Purpose: The occurrence of parathyroid carcinoma (PC) and atypical parathyroid neoplasm (APN) in multiple endocrine neoplasia type 1 (MEN1) is rare. The present paper reports the cases of 3 MEN1-PC/APN patients at our center and discusses the prevalence ...
An Song +8 more
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