Results 11 to 20 of about 12,302 (171)

MEN1 syndrome: an anusual case

Clinical Management Issues, 2015
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant endocrine disorder and is characterised by the concurrent appearance of adenomas of the parathyroid glands, neuroendocrine-enteropancreatic tumours, and pituitary adenomas, as well ...
Elena Guidetti, Monica Cevenini, Maria Luigia Cipollini, Martina Ferrata, Paola Tomassetti, Roberto Corinaldesi   +5 more
doaj   +2 more sources

Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene

World Journal of Surgical Oncology, 2011
The incidence of adrenal involvement in MEN1 syndrome has been reported between 9 and 45%, while the incidence of adrenocortical carcinoma (ACC) in MEN1 patients has been reported between 2.6 and 6%.
Kamakari Smaragda, Evangelou Konstantinos, Sakellariou Stratigoula, Zilos Athanassios, Dimitriou Nikoletta, Griniatsos John E, Korkolopoulou Penelope, Kaltsas Gregory   +7 more
doaj   +3 more sources

Diagnosis and Management of Multiple Endocrine Neoplasia Type 1 (MEN1) [PDF]

Hereditary Cancer in Clinical Practice, 2005
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited disorder, characterised by the occurrence of tumours of the parathyroid glands, the pancreatic islets, the pituitary gland, the adrenal glands and neuroendocrine carcinoid ...
Dreijerink Koen MA, Lips Cees JM
doaj   +2 more sources

Dependency of B-cell acute lymphoblastic leukemia and multiple myeloma cell lines on MEN1 extends beyond MEN1–KMT2A interaction [PDF]

, 2023
Menin/MEN1 is a scaffold protein that participates in proliferation, regulation of gene transcription, DNA damage repair, and signal transduction. In hematological malignancies harboring the KMT2A/MLL1 (MLLr) chromosomal rearrangements, the interaction ...
Franz Ketzer, Alexey Ushmorov, Tatjana Magdalena Wolffhardt, Stefano Telese, Thomas Wirth   +4 more
core   +1 more source

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs) [PDF]

, 2020
Neuroendocrine neoplasms (NENs) occur usually as sporadic tumours; however, rarely, they may arise in the context of a hereditary syndrome, such as multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterised by the combined ...
Avniel-Polak, Shani, Grozinsky-Glasberg, Simona, Bountra, Chas, Thakker, Rajesh V, Lines, Kate E   +4 more
core   +1 more source

Management for multiple endocrine neoplasia 1 during pregnancy： clinical and genetic analysis for a pedigree and review of literature [PDF]

Xin yixue, 2022
Objective To investigate the clinical characteristics and management strategies for multiple endocrine neoplasia 1 （MEN1） during pregnancy. Methods The gender, age, detailed medical history, clinical symptoms and signs, laboratory, imaging and ...
Ye Zhiwei, Deng Hongrong, Liu Zhigu, Lin Huimin, Xu Wen, Yao Bin
doaj   +1 more source

p.L105Vfs mutation in a family with thymic neuroendocrine tumor combined with MEN1: a case report

BMC Neurology, 2020
Background Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder arising from mutations of the MEN1 tumor suppressor gene on chromosome 11q13; MEN1 is characterized by the development of neuroendocrine tumors, including those ...
Hongjuan Zheng, Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Ying Yuan, Jianfei Fu   +7 more
doaj   +1 more source

Patients with MEN1 are at an increased risk for venous thromboembolism VTE risk in MEN1 [PDF]

, 2021
Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder predisposing to the development of multiple functional and non-functional neuroendocrine tumors (NETs). Only uncommon MEN1-associated functional NETs such as glucagonomas
Cochran, Craig, Piaggi, Paolo, Ortega-Sustache, Yashira M, Tepede, Aisha, Simonds, William F, Tirosh, Amit, Lee, Maya E, Agarwal, Sunita K, Blau, Jenny E, Mandl, Adel, Bansal, Rashika, Welch, James, Weinstein, Lee S   +12 more
core   +1 more source

Multiple Endocrine Neoplasia Type 1 (MEN1): Loss of One MEN1 Allele in Tumors and Monohormonal Endocrine Cell Clusters But Not in Islet Hyperplasia of the Pancreas [PDF]

, 2006
CONTEXT: The occurrence of multiple small pancreatic endocrine tumors in patients suffering from multiple endocrine neoplasia type 1 (MEN1) represents a unique possibility to study early neoplasms and their potential precursor lesions.
Thomas Rudolph, Paul Komminoth, Dralle, Henning, Gimm, Oliver, Eberhard Weihe, Komminoth, Paul,, Weihe, Eberhard, Tobias Henopp, Anlauf, Martin,, Gimm, Oliver,, Heitz, Philipp U,, Rudolph, Thomas, Klöppel, Günter,, Wolfram T. Knoefel, Dralle, Henning,, Perren, Aurel,, Raffel, Andreas,, Weihe, Eberhard,, Henopp, Tobias, Heitz, Philipp U., Andreas Raffel, Knoefel, Wolfram T,, Anlauf, Martin, Aurel Perren, Rudolph, Thomas,, Knoefel, Wolfram T., Perren, Aurel, Schmitt, Anja,, Komminoth, Paul, Martin Anlauf, Anja Schmitt, Oliver Gimm, Philipp U. Heitz, Henopp, Tobias,, Günter Klöppel, Klöppel, Günter, Schmitt, Anja, Henning Dralle, Raffel, Andreas   +38 more
core   +2 more sources

Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1

Respiratory Medicine Case Reports, 2017
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin.
Nobumasa Ohara, Masanori Kaneko, Masahiro Ikeda, Fumio Ishizaki, Kazuya Suzuki, Ryo Maruyama, Takeshi Komeyama, Kazuhiro Sato, Kenichi Togashi, Hiroyuki Usuda, Yuto Yamazaki, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi   +13 more
doaj   +1 more source