Results 31 to 40 of about 12,302 (171)

Generation and characterization of Men1 mutant mouse models for studying MEN1 disease

Journal of Pancreatology, 2019
. Patients with multiple endocrine neoplasia type 1 (MEN1) mutations are predisposed to MEN1 syndrome affecting various endocrine cell lineages. Following its identification in the late 1990s, laboratories around the world, including our own, used gene ...
Ya-kun Luo, MS, Razan A. Ziki, MS, Chang X. Zhang, PhD   +2 more
doaj   +1 more source

Role of MEN1 in B cell acute lymphoblastic leukemia

, 2023
noneB Cell Acute Lymphoblastic Leukemias is a heterogenous group of hematological disorder resulting in an impaired hematopoiesis because of an aberrant proliferation and blocked differentiation of immature lymphocytic cells, causing bone marrow failure.
TELESE, STEFANO
core  

MEN1 Gene Mutation and Reduced Expression Are Associated With Poor Prognosis in Pulmonary Carcinoids [PDF]

, 2014
Context: MEN1 gene alterations have been implicated in lung carcinoids, but their effect on gene expression and disease outcome is unknown. Objective: Our objective was to analyze MEN1 gene and expression anomalies in lung neuroendocrine neoplasms and ...
Gatti, Gaia, Papotti, Mauro, Swarts, Dorian RA, Henfling, Mieke ER, Ramaekers, Frans CS, Corbo, Vicenzo, Volante, Marco, Speel, Ernst-Jan M., Scarpa, Aldo, Van Criekinge, Wim, Swarts, Dorian R. A., Speel, Ernst-Jan M, van Engeland, Manon, Corbo, Vincenzo, Perren, Aurel, Ramaekers, Frans C. S., Henfling, Mieke E. R.   +16 more
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Multiple Endocrine Neoplasia Type 1 (MEN1)

, 2010
This chapter focuses on multiple endocrine neoplasia type 1 (MEN1) which is an autosomal dominantly inherited syndrome. The syndrome is characterized by the occurrence of tumors of the parathyroid glands, the pancreatic islets, the anterior pituitary ...
Cornelis J.M. Lips, van Nesselrooij, Bernadette P M, Höppener, Jo W M, van der Luijt, Rob B., Koen M.A. Dreijerink, Rob B. van der Luijt, Dreijerink, Koen M A, Jo W.M. Höppener, Lips, Cornelis J M, Bernadette P.M. van Nesselrooij   +9 more
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Bone phenotypes in multiple endocrine neoplasia type 1: survey on the MEN1 Florentine database

Endocrine Connections, 2022
Multiple endocrine neoplasia type 1 (MEN1) is a rare, inherited cancer syndrome characterized by the development of multiple endocrine and non-endocrine tumors.
Francesca Marini, Francesca Giusti, Teresa Iantomasi, Federica Cioppi, Maria Luisa Brandi   +4 more
doaj   +1 more source

MEN1 syndrome: an anusual case

Clinical Management Issues, 2013
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant endocrine disorder and is characterised by the concurrent appearance of adenomas of the parathyroid glands, neuroendocrine-enteropancreatic tumours, and pituitary adenomas, as well ...
Elena Guidetti, Monica Cevenini, Maria Luigia Cipollini, Martina Ferrata, Paola Tomassetti, Roberto Corinaldesi   +5 more
doaj   +1 more source

Multiple Endocrine Neoplasia Type 1 (MEN1): An Update and the Significance of Early Genetic and Clinical Diagnosis

Frontiers in Endocrinology, 2019
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in an autosomal dominant manner and characterized by a predisposition to a multitude of endocrine neoplasms primarily of parathyroid, enteropancreatic, and anterior ...
Crystal D. C. Kamilaris, Constantine A. Stratakis   +1 more
doaj   +1 more source

Animal models of MEN1.

, 2017
Animal models of cancer have been instrumental in advancing our understanding of the biology of tumor initiation and progression, in studying gene function and in performing preclinical studies aimed at testing novel therapies.
Natalia S Pellegata, Pellegata, N.S., Hermine Mohr, Mohr, H., Mohr H., Pellegata N. S.   +5 more
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The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit".

PLoS ONE, 2012
Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare hereditary cancer disorder characterized by tumors of the parathyroids, of the neuroendocrine cells, of the gastro-entero-pancreatic tract, of the anterior pituitary, and by non-endocrine ...
Ettore Luzi, Francesca Marini, Francesca Giusti, Gianna Galli, Loredana Cavalli, Maria Luisa Brandi   +5 more
doaj   +1 more source

Expressions of Cushing’s syndrome in multiple endocrine neoplasia type 1

Frontiers in Endocrinology, 2023
Cushing’s syndrome (CS) resulting from endogenous hypercortisolism can be sporadic or can occur in the context of familial disease because of pituitary or extra-pituitary neuroendocrine tumors.
William F. Simonds
doaj   +1 more source