Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma [PDF]
International Journal of Endocrinology, 2020 Objective. Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or ...
Luigia Cinque +12 more
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Case Report: A novel likely pathogenetic variant of the MEN1 gene in multiple endocrine neoplasia type 1 [PDF]
Frontiers in EndocrinologyBackgroundMultiple endocrine neoplasia type 1 (MEN1) is a rare disease caused by mutations in the oncosuppressor gene MEN1 and characterized by co-occurrence of tumors of the parathyroid gland, pancreas, and pituitary gland.
Mengli Sun +5 more
doaj +2 more sources
A novel mutation of the MEN1 gene in a patient with multiple endocrine neoplasia type 1 and recurrent fibromyxoid sarcoma – a case report [PDF]
BMC Medical Genetics, 2020 Background Multiple endocrine neoplasia type 1 (MEN1) syndrome is usually accompanied by endocrine tumors, but non-endocrine tumors can occur as well. However, the coexistence of MEN1 syndrome and malignant tumor such as low-grade fibromyxoid sarcoma has
Maja Radman, Tanja Milicevic
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An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment [PDF]
World Journal of Surgical OncologyThe menin protein, encoded by the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, serves as a critical regulator of cellular processes in human cancers.
Hao Li +6 more
doaj +2 more sources
MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10-Mediated Angiogenesis. [PDF]
Cancer SciMEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Wei C +17 more
europepmc +2 more sources
Multiple endocrine neoplasia type 1 with neuroglycopenic symptoms with a novel heterozygous MEN1 gene mutation [PDF]
World Journal of Surgical OncologyBackground Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by mutations in the MEN1 gene located on the long arm of chromosome 11. Case presentation.
Xinchen Jiang +4 more
doaj +2 more sources
Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 Gene [PDF]
Cells, 2022 Cholinergic neuronal networks in the hippocampus play a key role in the regulation of learning and memory in mammals. Perturbations of these networks, in turn, underlie neurodegenerative diseases. However, the mechanisms remain largely undefined. We have
Anosha Kiran Ulfat +3 more
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Management for multiple endocrine neoplasia 1 during pregnancy： clinical and genetic analysis for a pedigree and review of literature [PDF]
Xin yixue, 2022 Objective To investigate the clinical characteristics and management strategies for multiple endocrine neoplasia 1 （MEN1） during pregnancy. Methods The gender, age, detailed medical history, clinical symptoms and signs, laboratory, imaging and ...
Ye Zhiwei, Deng Hongrong, Liu Zhigu, Lin Huimin, Xu Wen, Yao Bin
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The Turkish Journal of Gastroenterology, 2020 Background & Aims: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant syndrome characterized by tumors arising from endocrine glands with no specific genotype-phenotype correlation. Herein, we report the largest Turkish kindred with MEN1
Coşkun Özer Demirtaş +4 more
doaj +1 more source
Frontiers in Endocrinology, 2022 BackgroundMultiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by mutations in MEN1 tumor suppressor gene.Case PresentationA 53-year-old Chinese female was admitted to Division of Endocrinology, Tongji Hospital, for ...
Fuqiong Chen +9 more
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