Results 21 to 30 of about 2,522,691 (166)

The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit".

PLoS ONE, 2012
Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare hereditary cancer disorder characterized by tumors of the parathyroids, of the neuroendocrine cells, of the gastro-entero-pancreatic tract, of the anterior pituitary, and by non-endocrine ...
Ettore Luzi, Francesca Marini, Francesca Giusti, Gianna Galli, Loredana Cavalli, Maria Luisa Brandi   +5 more
doaj   +1 more source

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

Cell Reports, 2017
While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis.
Koen M.A. Dreijerink, Anna C. Groner, Erica S.M. Vos, Alba Font-Tello, Lei Gu, David Chi, Jaime Reyes, Jennifer Cook, Elgene Lim, Charles Y. Lin, Wouter de Laat, Prakash K. Rao, Henry W. Long, Myles Brown   +13 more
doaj   +1 more source

p.L105Vfs mutation in a family with thymic neuroendocrine tumor combined with MEN1: a case report

BMC Neurology, 2020
Background Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder arising from mutations of the MEN1 tumor suppressor gene on chromosome 11q13; MEN1 is characterized by the development of neuroendocrine tumors, including those ...
Hongjuan Zheng, Shishi Zhou, Wanfen Tang, Qinghua Wang, Xia Zhang, Xiayun Jin, Ying Yuan, Jianfei Fu   +7 more
doaj   +1 more source

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype [PDF]

, 2013
PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
OCCHI, GIANLUCA, Pellegata, NS, Pardi E, Giampaolo Trivellin, Franco Mantero (392960), Cetani, F., Carla Scaroni, Sidarovich V, Carla Scaroni (392961), CIATO, DENIS, Sidarovich, V, Ciato, D., Franco Mantero, Denis Ciato (392953), Regazzo, D, Ferasin, S, Viktoryia Sidarovich, Quattrone, A., Giampaolo Trivellin (106006), Pardi, E, MANTERO, FRANCO, Francesca Boaretto (392952), Bobisse S, Pellegata NS, Denis Ciato, SCARONI, CARLA, Korbonits M, Márta Korbonits (59514), Opocher, G., Sara Bobisse (392954), Regazzo, D., Gianluca Occhi (38330), Daniela Regazzo, Viktoryia Sidarovich (392959), Francesca Boaretto, Daniela Regazzo (392951), REGAZZO, DANIELA, Korbonits, M., Filomena Cetani, Scaroni, C, Ciato, D, Natalia S Pellegata, Mantero, F, Elena Pardi (392957), Pellegata, N.S., Giuseppe Opocher (260071), Giuseppe Opocher, Scaroni, C., Alessandro Quattrone (220189), Cetani F, Bobisse, S, Boaretto, F, Mantero, F., Trivellin G, Quattrone, A, Elena Pardi, Márta Korbonits, Sergio Ferasin, Trivellin, G, Sidarovich, V., Filomena Cetani (392956), BOARETTO, FRANCESCA, Occhi, G., Natalia S. Pellegata (392958), Bobisse, S., Sara Bobisse, Trivellin, G., Boaretto, F., Sergio Ferasin (392955), Gianluca Occhi, Alessandro Quattrone, OPOCHER, GIUSEPPE, FERASIN, SERGIO, Opocher, G, Ferasin, S., Korbonits, M, Pardi, E., Occhi, G, Quattrone A, Cetani, F   +79 more
core   +2 more sources

Generation of isogenic and homozygous MEN1 mutant cell lines from patient-derived iPSCs using CRISPR/Cas9

Stem Cell Research, 2023
MEN1, an autosomal dominant disorder caused by mutations in the tumor suppressor gene MEN1, manifests with co-occurrence of multiple endocrine/neuroendocrine neoplasms. An iPSC line derived from an index patient carrying the mutation c.1273C>T (p.Arg465*)
Naomi Even-Zohar, Derya Metin-Armagan, Anat Ben-Shlomo, Dhruv Sareen, Shlomo Melmed   +4 more
doaj   +1 more source

A Novel MEN1 Gene Mutation in Leukocyte and Parathyroid Tumors of a MEN Type 1 Patient [PDF]

, 2002
Multiple endocrine neoplasia type 1 (MEN1) is an inherited genomic disorder involving the MEN1 tumor suppressor gene. Many germline mutations of the gene have been previously reported. We identified a novel MEN1 germline mutation in the DNA of a Japanese
WAKAHARA, Shigeyuki, MIYAMORI, Isamu, TANIGUCHI, Naomi, KONOSHITA, Tadashi   +3 more
core   +1 more source

MEN1 syndrome: an anusual case

Clinical Management Issues, 2013
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant endocrine disorder and is characterised by the concurrent appearance of adenomas of the parathyroid glands, neuroendocrine-enteropancreatic tumours, and pituitary adenomas, as well ...
Elena Guidetti, Monica Cevenini, Maria Luigia Cipollini, Martina Ferrata, Paola Tomassetti, Roberto Corinaldesi   +5 more
doaj   +1 more source

MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas. [PDF]

, 2012
Multiple endocrine neoplasia type 1 (MEN1) is characterized by the combined occurrence of pituitary, pancreatic, and parathyroid tumors showing loss of heterozygosity in the putative tumor suppressor gene MEN1.
Jeyabalan, J, Reed, AA, Harding, B, Lemos, MC, Walls, GV, Christie, PT, Seymour, L, Seymour, Leonard, Thakker, RV, Piret, S, Walls, Gerard, Stuckey, DJ, Bazan-Peregrino, M, Thakker, Rajesh, Tyler, DJ, Clarke, Kieran, Javid, M, Tyler, Damian, Clarke, K, Ansorge, O   +19 more
core   +1 more source

Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism Induced by Multiple Endocrine Neoplasia 1—A Case Report

Diagnostics, 2022
Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by the occurrence of two or more endocrine gland tumors. Here, we show a case of a 52-year-old man diagnosed with MEN1 through gastrinoma, parathyroid adenoma and gene detection.
Zhenping Han, Tingting Li, Siyi Wang, Li Gao, Ying Hu, Yu Zhao, Jieping Yan   +6 more
doaj   +1 more source

Phenotypes Associated With MEN1 Syndrome: A Focus on Genotype-Phenotype Correlations

Frontiers in Endocrinology, 2020
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited tumor syndrome, associated with parathyroid, pituitary, and gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs).
Chiara Mele, Chiara Mele, Monica Mencarelli, Marina Caputo, Marina Caputo, Stefania Mai, Loredana Pagano, Gianluca Aimaretti, Gianluca Aimaretti, Massimo Scacchi, Alberto Falchetti, Alberto Falchetti, Paolo Marzullo, Paolo Marzullo   +13 more
doaj   +1 more source