Results 11 to 20 of about 2,522,691 (166)

Bilateral adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1 (MEN1) and a novel mutation in the MEN1 gene

World Journal of Surgical Oncology, 2011
The incidence of adrenal involvement in MEN1 syndrome has been reported between 9 and 45%, while the incidence of adrenocortical carcinoma (ACC) in MEN1 patients has been reported between 2.6 and 6%.
Kamakari Smaragda, Evangelou Konstantinos, Sakellariou Stratigoula, Zilos Athanassios, Dimitriou Nikoletta, Griniatsos John E, Korkolopoulou Penelope, Kaltsas Gregory   +7 more
doaj   +4 more sources

MEN1 syndrome: an anusual case

Clinical Management Issues, 2015
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant endocrine disorder and is characterised by the concurrent appearance of adenomas of the parathyroid glands, neuroendocrine-enteropancreatic tumours, and pituitary adenomas, as well ...
Elena Guidetti, Monica Cevenini, Maria Luigia Cipollini, Martina Ferrata, Paola Tomassetti, Roberto Corinaldesi   +5 more
doaj   +2 more sources

Insulinoma Associated with MEN1 Syndrome: A Case of Persistent Hypoglycemia in a School-aged Child

JCRPE
Insulinoma is a rare cause of non-ketotic hypoglycemia, both in adults and in children. Pediatric patients account for approximately 5% of all cases, mostly due to isolated benign lesions, but insulinoma may also be part of a multiple endocrine neoplasia
Rodrigo Lemus-Zepeda, Aura María Salazar-Solarte, Diana Marcela Vasquez-Forero, Mario Jr. Angulo-Mosquera, Liliana Mejía-Zapata   +4 more
doaj   +2 more sources

MEN1 Gene Mutation and Reduced Expression Are Associated With Poor Prognosis in Pulmonary Carcinoids [PDF]

, 2014
Context: MEN1 gene alterations have been implicated in lung carcinoids, but their effect on gene expression and disease outcome is unknown. Objective: Our objective was to analyze MEN1 gene and expression anomalies in lung neuroendocrine neoplasms and ...
Gatti, Gaia, Papotti, Mauro, Swarts, Dorian RA, Henfling, Mieke ER, Ramaekers, Frans CS, Corbo, Vicenzo, Volante, Marco, Speel, Ernst-Jan M., Scarpa, Aldo, Van Criekinge, Wim, Swarts, Dorian R. A., Speel, Ernst-Jan M, van Engeland, Manon, Corbo, Vincenzo, Perren, Aurel, Ramaekers, Frans C. S., Henfling, Mieke E. R.   +16 more
core   +4 more sources

Mutational and large deletion study of genes implicated in hereditary forms of primary hyperparathyroidism and correlation with clinical features. [PDF]

PLoS ONE, 2017
The aim of this study was to carry out genetic screening of the MEN1, CDKN1B and AIP genes, both by direct sequencing of the coding region and multiplex ligation-dependent probe amplification (MLPA) assay in the largest monocentric series of Italian ...
Elena Pardi, Simona Borsari, Federica Saponaro, Fausto Bogazzi, Claudio Urbani, Stefano Mariotti, Francesca Pigliaru, Chiara Satta, Fabiana Pani, Gabriele Materazzi, Paolo Miccoli, Lorena Grantaliano, Claudio Marcocci, Filomena Cetani   +13 more
doaj   +1 more source

Lung adenocarcinoma and adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1

Respiratory Medicine Case Reports, 2017
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by heterozygous germline mutations in the tumor suppressor gene MEN1, which encodes a nuclear protein, menin.
Nobumasa Ohara, Masanori Kaneko, Masahiro Ikeda, Fumio Ishizaki, Kazuya Suzuki, Ryo Maruyama, Takeshi Komeyama, Kazuhiro Sato, Kenichi Togashi, Hiroyuki Usuda, Yuto Yamazaki, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi   +13 more
doaj   +1 more source

Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing

BMC Medical Genetics, 2017
Background Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary.
Bo-Young Kim, Mi-Hyun Park, Hae-Mi Woo, Hye-Yeong Jo, Ji Hoon Kim, Hyung Jin Choi, Soo Kyung Koo   +6 more
doaj   +1 more source

Clinical and molecular characterization of parathyroid carcinoma in multiple endocrine neoplasia type 1

Endocrine Connections, 2023
Nineteen cases of parathyroid carcinoma in patients with multiple endocrine neoplasia type 1 have been reported in the literature, of which 11 carry an inactivating germline mutation in the MEN1 gene.
Sara Lomelino Pinheiro, Ana Saramago, Branca Maria Cavaco, Carmo Martins, Valeriano Leite, Tiago Nunes da Silva   +5 more
doaj   +1 more source

Generation and characterization of Men1 mutant mouse models for studying MEN1 disease

Journal of Pancreatology, 2019
. Patients with multiple endocrine neoplasia type 1 (MEN1) mutations are predisposed to MEN1 syndrome affecting various endocrine cell lineages. Following its identification in the late 1990s, laboratories around the world, including our own, used gene ...
Ya-kun Luo, MS, Razan A. Ziki, MS, Chang X. Zhang, PhD   +2 more
doaj   +1 more source

Multiple endocrine neoplasia type 1: a new germline “homozygous” variant (c.201delC) caused by detection errors

Hereditary Cancer in Clinical Practice, 2022
Background Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome caused by germline variants in the MEN1 gene located on chromosome 11q13.
Fan Zhang, Xiaohui Yu, Xiaoli Wang, Hua Shao   +3 more
doaj   +1 more source