Results 1 to 10 of about 12,741 (112)

CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials [PDF]

Nature Communications
Menin inhibitors have entered clinical trials for histone lysine methyltransferase 2 A (KMT2A)-rearranged and nucleophosmin 1 (NPM1)-mutant acute leukemias and are demonstrating promising activity.
Wallace Bourgeois, Hannah E. Rice, Daniela V. Wenge, Florian Perner, Hong Yue, Brandon D. Regalado, George Wan, Jan C. Schroeder, Alba Sommerschield, Charlie Hatton, Shivendra Singh, Sweta Singh, Shipra Bijpuria, Brian M. McKeever, William H. Miller, Jordan F. Safer, Sumaiya Iqbal, Jennifer A. Perry, Eric S. Fischer, John G. Doench, Gerard M. McGeehan, Jevon A. Cutler, Scott A. Armstrong   +22 more
doaj   +2 more sources

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Cell Reports, 2018
Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Huaxi Xu, Honghua Zheng, Hao Sun
exaly   +3 more sources

Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer

Cell Reports, 2017
While the multiple endocrine neoplasia type 1 (MEN1) gene functions as a tumor suppressor in a variety of cancer types, we explored its oncogenic role in breast tumorigenesis.
Erica S M Vos, Lei Gu, Henry W Long
exaly   +3 more sources

Clinical research progress of menin inhibitors for acute myeloid leukemia: latest updates from the 2025 ASH Annual Meeting [PDF]

Experimental Hematology & Oncology
Menin inhibition has emerged as a promising therapeutic strategy for acute myeloid leukemia (AML) driven by KMT2A rearrangements or NPM1 mutations. Novel menin inhibitors, including revumenib, bleximenib, ziftomenib, and enzomenib, are currently under ...
Chenchen Ma, Siyuan Cui, Jingyi Wang
doaj   +2 more sources

Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma [PDF]

Scientific Reports
Middle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss.
Tomomi Yamamoto-Fukuda, Naotaro Akiyama, Hiromi Kojima   +2 more
doaj   +2 more sources

Menin inhibitors from monotherapies to combination therapies: clinical trial updates from 2024 ASH annual meeting

Journal of Hematology and Oncology
Menin inhibitors, which target the KMT2A-menin protein-protein interaction to inhibit blasts proliferation and induce differentiation, have demonstrated potential effects on acute leukemia subtypes characterized by overexpression of HOXA gene cluster and
Gejia Cao, Haixiao Zhang, Shu Sun, Hong-Hu Zhu   +3 more
exaly   +2 more sources

Identification of LncRNAs scaffolding a chromatin-associated gene regulatory complex in breast cancer cells comprising ERα, DOT1L and menin [PDF]

Cell Communication and Signaling
In Estrogen Receptor (ER)-positive Breast Cancer (BC), the development of resistance to endocrine therapies remains a significant clinical challenge, often linked to transcriptional and epigenetic deregulations.
Viola Melone, Annamaria Salvati, Luigi Palo, Domenico Palumbo, Domenico Memoli, Maria Ianniello, Mehrnoush Nikzaban, Aurora Casaburi, Jessica Lamberti, Francesca Rizzo, Alessandro Weisz, Giovanni Nassa, Roberta Tarallo   +12 more
doaj   +2 more sources

Saccharomyces cerevisiae: Multifaceted Applications in One Health and the Achievement of Sustainable Development Goals

Encyclopedia, 2023
Saccharomyces cerevisiae (SC), a yeast with an extensive history in food and beverage fermentations, is increasingly acknowledged for its multifaceted application in promoting and benefiting all aspects of a ‘One Health’ approach, including the ...
Nathalie Ballet, Sarah Renaud, Hugo Roume, Fanny George, Pascal Vandekerckove, Mickaël Boyer, Mickaël Durand-Dubief   +6 more
doaj   +1 more source

Antisense Oligonucleotide-Based Therapeutic against Menin for Triple-Negative Breast Cancer Treatment

Biomedicines, 2021
The tumor suppressor menin has dual functions, acting either as a tumor suppressor or as an oncogene/oncoprotein, depending on the oncological context.
Dang Tan Nguyen, Thi Khanh Le, Clément Paris, Chaïma Cherif, Stéphane Audebert, Sandra Oluchi Udu-Ituma, Sébastien Benizri, Philippe Barthélémy, François Bertucci, David Taïeb, Palma Rocchi   +10 more
doaj   +1 more source

The effect of yeast-derived β-glucans in reducing the adverse outcome of Lawsonia intracellularis in finishing pigs

Frontiers in Animal Science, 2023
IntroductionChronic diarrhoea is one of the most recurrent health issues in pig herds. Among Q9 the causative agents of diarrhoea, Lawsonia intracellularis is quite frequent with worldwide distribution leading to detrimental economical losses, as a ...
Lamya Rhayat, Gaël Even, Gaël Even, Tadele G. Kiros, Géraldine Kuhn, Ségolène Lebrun-Ruer, Ségolène Lebrun-Ruer, Christophe Audebert, Christophe Audebert, Julie Schulthess   +9 more
doaj   +1 more source