Results 31 to 40 of about 18,346 (199)

Menin orchestrates hepatic glucose and fatty acid uptake via deploying the cellular translocation of SIRT1 and PPARγ

Cell & Bioscience, 2023
Background Menin is a scaffold protein encoded by the Men1 gene, which interacts with various transcriptional proteins to activate or repress cellular processes and is a key mediator in multiple organs.
Tingjun Liu, Ranran Li, Lili Sun, Zhongjin Xu, Shengxuan Wang, Jingxuan Zhou, Xuanning Wu, Kerong Shi   +7 more
doaj   +1 more source

Menin Coordinates C/EBPβ-Mediated TGF-β Signaling for Epithelial-Mesenchymal Transition and Growth Inhibition in Pancreatic Cancer

Molecular Therapy: Nucleic Acids, 2019
Menin displays either tumor suppression or promotion functions in a context-dependent manner. Previously, we proposed that Menin acts as a tumor suppressor by inhibiting cell growth in pancreatic ductal adenocarcinoma (PDAC), whereas the relationship ...
Peng Cheng, Ying Chen, Tian-lin He, Chao Wang, Shi-wei Guo, Hao Hu, Chen-ming Ni, Gang Jin, Yi-jie Zhang   +8 more
doaj   +1 more source

Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer

Cancer Cell International, 2022
Background Ovarian cancer (OC) is characterized by a low response rate and high frequency of resistance development to currently available treatments.
Elena Alexandrova, Jessica Lamberti, Domenico Memoli, Claudia Quercia, Viola Melone, Francesca Rizzo, Roberta Tarallo, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz   +9 more
doaj   +1 more source

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

PLoS Genetics, 2006
Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to
Peter C Scacheri, Sean Davis, Duncan T Odom, Gregory E Crawford, Stacie Perkins, Mohamad J Halawi, Sunita K Agarwal, Stephen J Marx, Allen M Spiegel, Paul S Meltzer, Francis S Collins   +10 more
doaj   +2 more sources

Spatiotemporal Patterns of Menin Localization in Developing Murine Brain: Co-Expression with the Elements of Cholinergic Synaptic Machinery

Cells, 2021
Menin, a product of MEN1 (multiple endocrine neoplasia type 1) gene is an important regulator of tissue development and maintenance; its perturbation results in multiple tumors—primarily of the endocrine tissue.
Shadab Batool, Jawwad Zaidi, Basma Akhter, Anosha Kiran Ulfat, Frank Visser, Naweed I. Syed   +5 more
doaj   +1 more source

MEN1/Menin regulates milk protein synthesis through mTOR signaling in mammary epithelial cells

Scientific Reports, 2017
The MEN1 gene, which encodes the protein Menin, was investigated for its regulatory role in milk protein synthesis in mammary glands. Menin responds to nutrient and hormone levels via the PI3K/Akt/mTOR pathway. Bovine mammary epithelial cells and tissues
Honghui Li, Xue Liu, Zhonghua Wang, Xueyan Lin, Zhengui Yan, Qiaoqiao Cao, Meng Zhao, Kerong Shi   +7 more
doaj   +1 more source

The menin tumor suppressor protein is phosphorylated in response to DNA damage. [PDF]

PLoS ONE, 2011
Multiple endocrine neoplasia type 1 (MEN1) is a heritable cancer syndrome characterized by tumors of the pituitary, pancreas and parathyroid. Menin, the product of the MEN1 gene, is a tumor suppressor protein that functions in part through the regulation
Joshua Francis, Wenchu Lin, Orit Rozenblatt-Rosen, Matthew Meyerson   +3 more
doaj   +1 more source

Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation

International Journal of Endocrinology, 2015
Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell ...
Vaishali I. Parekh, Sita D. Modali, Shruti S. Desai, Sunita K. Agarwal   +3 more
doaj   +1 more source

Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis

Genes and Diseases
Bladder cancer (BLCA) is a common malignant tumor of the urinary system, with significant morbidity and mortality rates worldwide. The MEN1 gene, encoding the menin protein, plays a regulatory role in several cancers. However, the role played by menin in
Qing Shi, Xiang Pan, Shiheng Zhang, Mengyuan Wu, Meiqi Xu, Yun-Qi Li, Li Zhong, Zi-Qi Wang, Wanhai Xu, Yakun Luo   +9 more
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source