Results 11 to 20 of about 18,346 (199)
Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation [PDF]
Neoplasia: An International Journal for Oncology Research, 2007 Menin is the protein product of the MEN1 tumorsuppressor gene; one allele of MEN1 is inactivated in the germ line of patients with “multiple endocrine neoplasia type 1” (MEN1) cancer syndrome.
Sunita K. Agarwal +7 more
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Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism [PDF]
Cancers, 2020 The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments.
Chih-Wei Chou +11 more
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Epigenetic regulation by the menin pathway [PDF]
Endocrine-Related Cancer, 2017 There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model to investigate how NETs develop and the underlying mechanisms.
Zijie, Feng, Jian, Ma, Xianxin, Hua
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GenesThe protein menin is encoded by the MEN1 gene and primarily serves as a nuclear scaffold protein, regulating gene expression through its interaction with and regulation of chromatin modifiers and transcription factors. While the scope of menin’s functions continues to expand, one area of growing investigation is the role of menin in cancer.
Ariana D. Majer +2 more
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FBP1 Is an Interacting Partner of Menin [PDF]
International Journal of Endocrinology, 2014 Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by tumors in multiple endocrine tissues such as the parathyroid glands, the pituitary gland, and the enteropancreatic neuroendocrine tissues.
Shadia Zaman +6 more
doaj +3 more sources
The Role of Menin in Parathyroid Tumorigenesis
, 2009 Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood.
Davenport, Colin, Agha, Amar
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MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10-Mediated Angiogenesis. [PDF]
Cancer SciMEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Wei C +17 more
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Ezh2 Inhibits the Differentiation of Short-Lived Effector CD8<sup>+</sup> T Cells and Promotes T Cell-Dependent Antitumor Immunity. [PDF]
Cancer SciThe antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Takagi K +5 more
europepmc +2 more sources
, 2022 Structures, models, trajectories, and data files for the paper "Acquired MEN1 mutations mediate resistance to Menin ...
Sukrit Singh
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The role of menin in bone pathology [PDF]
Endocrine Connections, 2022 Multiple endocrine neoplasia type 1 (MEN1) is the most common cause of hereditary primary hyperparathyroidism (PHPT). Bone disorders are considered one of the key symptoms in PHPT present with the significant reduction in bone mineral density and low-energy fractures. Previously, these bone disorders were believed to be caused solely by the increase in
Anna Gorbacheva +4 more
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