Results 41 to 50 of about 18,346 (199)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Differential expression of menin in various adrenal tumors [PDF]

Cancer, 2001
Adrenocortical tumors occur as sporadic tumors, as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome, or as part of other hereditary disorders. MEN1 is a tumor suppressor gene located on chromosome 11q13 that encodes a 610-amino acid protein called menin, and plays an important role in the development of MEN1 syndrome.
M M, Bhuiyan, M, Sato, K, Murao, H, Imachi, H, Namihira, T, Ishida, J, Takahara, A, Miyauchi   +7 more
openaire   +2 more sources

Menin stimulates homology-directed DNA repair. [PDF]

, 2010
Menin, the nuclear protein encoded by the Multiple Endocrine Neoplasia type 1 (MEN1) gene, acts as a tumor suppressor. It interacts with a large number of proteins involved in chromatin modification, transcription, cell cycle checkpoint and DNA repair ...
Esposito I., S. Agnese, M. Galgani, V.E. Avvedimento, Galgani M., Agnese S., Esposito, I., Avvedimento, V.E., Gallo A., Agnese, S., AVVEDIMENTO, VITTORIO ENRICO, Galgani, M., I. Esposito, A. Gallo, Gallo, A.   +14 more
core   +2 more sources

Multiple endocrine neoplasia type 1 with Zollinger–Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry

Frontiers in Endocrinology, 2023
BackgroundMultiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the occurrence of multiple epithelial neuroendocrine tumors (NETs) and non-NETs in various organs. MEN1 encodes a 610-amino acid-long tumor suppressor
Noriko Kimura, Noriko Kimura, Yasuji Hirata, Nozomu Iwashiro, Hiroshi Kijima, Shinobu Takayasu, Satoshi Yamagata, Satoshi Yamagata, Satoru Sakihara, Satoru Sakihara, Shinya Uchino, Masanori Ohara   +11 more
doaj   +1 more source

Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers

Molecules, 2023
Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition of the high-
Qing Shi, Meiqi Xu, Zhijian Kang, Manjie Zhang, Yakun Luo   +4 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. [PDF]

PLoS ONE, 2006
Transcription factor Cdx4 and transcriptional coregulator menin are essential for Hoxa9 expression and normal hematopoiesis. However, the precise mechanism underlying Hoxa9 regulation is not clear.Here, we show that the expression level of Hoxa9 is ...
Jizhou Yan, Ya-Xiong Chen, Angela Desmond, Albert Silva, Yuqing Yang, Haoren Wang, Xianxin Hua   +6 more
doaj   +1 more source

Capturing Hu Antigen R Domain Closure Through Supervised Molecular Dynamics Simulations

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HuR is a therapeutically relevant RNA‐binding protein that switches from an open apo form to a closed RNA‐bound one. Its atomistic detail is unknown. Here, Supervised Molecular Dynamics is applied for the first time to an intramolecular event: a multistep supervision of interdomain distances reproduces a plausible closure pathway and reveals transient ...
Chiara Cavastracci Strascia, Andrea Dodaro, Gianluca Novello, Silvia Menin, Mattia Sturlese, Veronica Salmaso, Stefano Moro   +6 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML

HemaSphere, 2023
Chromosomal translocations involving the NUP98 locus are among the most prevalent rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is characterized by high expression of HOXA and MEIS1 genes and is associated with poor ...
Milad Rasouli, Helen Blair, Selina Troester, Katarzyna Szoltysek, Rachel Cameron, Minoo Ashtiani, Anja Krippner-Heidenreich, Florian Grebien, Gerard McGeehan, C. Michel Zwaan, Olaf Heidenreich   +10 more
doaj   +1 more source