Results 21 to 30 of about 18,346 (199)

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein–protein interactions

Scientific Reports, 2023
Protein–protein interactions (PPIs) play a critical role in all biological processes. Menin is tumor suppressor protein, mutated in multiple endocrine neoplasia type 1 syndrome and has been shown to interact with multiple transcription factors including (
Gurjeet Kaur, Manisha Prajapat, Harvinder Singh, Phulen sarma, Sanjay kumar Bhadada, Nishant Shekhar, Saurabh Sharma, Shweta Sinha, Subodh kumar, Ajay Prakash, Bikash Medhi   +10 more
doaj   +1 more source

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study. [PDF]

Hematol Oncol
ABSTRACT Nucleoporin 98 rearrangements (NUP98re) occur in a wide range of hematologic malignancies including acute leukemias with a variety of fusion partners. NUP98re is associated with adverse prognosis, especially in children. We aimed to better understand the genomics of acute leukemias with NUP98re including fusion partners and co‐occurring ...
Batayneh O, Danziger N, Moein M, Naji NS, Pavlick D, Ross JS, Marcus C, Ho C, Gentile T, Zhou Z, Pasquina LW.   +10 more
europepmc   +2 more sources

Loss of tumor suppressor menin expression in high grade cholangiocarcinomas

BMC Research Notes, 2023
Background MEN1, which codes for the protein menin, is a tumor suppressor in neuroendocrine tissue. In cholangiocarcinoma (CCA) cell lines the overexpression of menin decreased proliferation, angiogenesis, migration, and invasion in vitro and in ...
Terry C. Lairmore, Jehan Abdulsattar, Arrigo De Benedetti, Runhua Shi, Shile Huang, Md Imtiaz Khalil, Stephan N. Witt   +6 more
doaj   +1 more source

Hypothalamic Menin regulates systemic aging and cognitive decline.

PLoS Biology, 2023
Aging is a systemic process, which is a risk factor for impaired physiological functions, and finally death. The molecular mechanisms driving aging process and the associated cognitive decline are not fully understood.
Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan, Jie Zhang   +15 more
doaj   +1 more source

Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration

Cell Communication and Signaling, 2018
Background Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroendocrine tumors (PNETs).
Masoud Razmara, Azita Monazzam, Britt Skogseid   +2 more
doaj   +1 more source

Expression of Menin in Parathyroid Tumors [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2000
The multiple endocrine neoplasia type 1 (MEN1) gene seems to be a tumor suppressor that encodes a 610-amino acid protein termed menin and that plays an important role in the development of MEN1 syndrome. Recent reports indicate that heterozygous germline mutations of this gene are responsible for the disease onset of MEN1. In this study we examined the
M M, Bhuiyan, M, Sato, K, Murao, H, Imachi, H, Namihira, J, Takahara   +5 more
openaire   +2 more sources

The Role of Menin in Hematopoiesis [PDF]

, 2009
In the hematopoietic system, menin was found to interact with MLL, a large protein encoded by the mixed linage leukemia gene that acts as a histone H3 methyltransferase. The MLL gene is a recurrent target for translocations in both acute myeloid and acute lymphoid leukemias.
Ivan, Maillard, Jay L, Hess
openaire   +2 more sources

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

Karin Smirnoff: Sitten menin kotiin

, 2022
Arvio teoksesta Karin Smirnoff: Sitten menin kotiin (Sen for jag hem). Suom. Outi Menna. Tammi 2022.
Vaismaa, Riitta
core   +1 more source

Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.

PLoS ONE, 2012
Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes
Sunita K Agarwal, Raja Jothi
doaj   +1 more source