Results 51 to 60 of about 12,302 (171)

Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice

BMC Cancer, 2010
Background Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology.
Tong Wei-Ming, Lu Jieli, Carreira Christine, Fontanière Sandra, Seigne Christelle, Fontanière Bernard, Wang Zhao-Qi, Zhang Chang, Frappart Lucien   +8 more
doaj   +1 more source

Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism Induced by Multiple Endocrine Neoplasia 1—A Case Report

Diagnostics, 2022
Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by the occurrence of two or more endocrine gland tumors. Here, we show a case of a 52-year-old man diagnosed with MEN1 through gastrinoma, parathyroid adenoma and gene detection.
Zhenping Han, Tingting Li, Siyi Wang, Li Gao, Ying Hu, Yu Zhao, Jieping Yan   +6 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Multiple endocrine neoplasia type 1 variants and phenocopies

Терапевтический архив, 2014
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disease due to a mutation in the MEN1 tumor suppressor gene. The risk of the disease in first-degree relatives of MEN1 mutation carriers is 50%.
E O Mamedova, N G Mokrysheva, E G Przhiialkovskaia, E A Pigarova, L Ia Rozhinskaia, A N Tiul'pakov   +5 more
doaj  

From Stigma to Support: Exploring Perceptions of Menstrual Leave Policies in European Workplaces

Gender, Work &Organization, EarlyView.
ABSTRACT Menstrual leave is an emerging reproductive health organizational policy gaining attention in Europe but research remains limited. Drawing on 45 semi‐structured interviews with menstruating and nonmenstruating workers in Croatia, Germany, and Italy, we applied thematic analysis to explore workplace perceptions of menstruation and menstrual ...
Paula E. Wasner, Lilith A. Whiley, Olivia A. Bettella, Carolina Maldonado, Sarah E. Stutterheim   +4 more
wiley   +1 more source

Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus

Clinics, 2011
BACKGROUND: The molecular mechanisms involved in the genesis of the adrenocortical lesions seen in MEN1 syndrome (ACL-MEN1) remain poorly understood; loss of heterozygosity at 11q13 and somatic mutations of MEN1 are not usually found in these lesions ...
Marcia Helena Soares Costa, Sorahia Domenice, Rodrigo Almeida Toledo, Delmar Muniz L. Junior, Ana Claudia Latronico, Emilia Modolo Pinto, Sergio Pereira Almeida Toledo, Berenice Bilharinho Mendonca, Maria Candida Barisson Villares Fragoso   +8 more
doaj   +1 more source

Phenotypes Associated With MEN1 Syndrome: A Focus on Genotype-Phenotype Correlations

Frontiers in Endocrinology, 2020
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited tumor syndrome, associated with parathyroid, pituitary, and gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs).
Chiara Mele, Chiara Mele, Monica Mencarelli, Marina Caputo, Marina Caputo, Stefania Mai, Loredana Pagano, Gianluca Aimaretti, Gianluca Aimaretti, Massimo Scacchi, Alberto Falchetti, Alberto Falchetti, Paolo Marzullo, Paolo Marzullo   +13 more
doaj   +1 more source

Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB‐amplified renal cell carcinoma: a comprehensive study of 15 cases

Histopathology, EarlyView.
This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow, Melissa Y. Tjota, Jung Woo Kwon, Tatjana Antic   +3 more
wiley   +1 more source

Ultrasound-guided microwave ablation in the treatment of recurrent primary hyperparathyroidism in a patient with MEN1: a case report

Frontiers in Endocrinology, 2023
BackgroundMultiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine syndrome caused by the mutation in the tumor suppressor gene MEN1. The recurrence rate of primary hyperparathyroidism (PHPT) in patients with MEN1 after parathyroidectomy ...
Zhoujun Liu, Yueting Zhao, Xue Han, Xin Hu, Yuzhi Zhang, Lan Xu, Guofang Chen, Guofang Chen, Chao Liu, Chao Liu, Shuhang Xu   +10 more
doaj   +1 more source

Do Family Changes Constitute a Comprehensive Demographic Shift? A Comparison of the Spatial Dynamics of Five Family Changes in Switzerland (1969–2023)

Tijdschrift voor Economische en Sociale Geografie, EarlyView.
Abstract Several theories have been proposed to explain the family changes that have occurred in Europe since the mid‐1960s. It is often assumed that as these changes occurred simultaneously; they have a common origin and represent the same demographic shift.
Adrita Banerjee, Yoann Doignon, Oumar Mbath, Amira Hamieh, Philippe Wanner   +4 more
wiley   +1 more source