Results 61 to 70 of about 12,302 (171)

Prolactinomas in the transition from adolescence to young adulthood: A multicentre, retrospective study from the TALENT group

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Prolactinomas in the transition age present unique challenges; treatment strategies and long‐term outcomes in this population remain incompletely characterised. This is a multicentre, retrospective study of 110 consecutive patients (33 males) with prolactinomas, aged 15–25 years, across five Italian referral centres (2010–2025).
Dario De Alcubierre, Claudia Giavoli, Tiziana Feola, Lorenzo Cerroni, Ludovica Vincenzi, Eriselda Profka, Aurora Pedroli, Giulia Puliani, Rosa Pirchio, Marta Tenuta, Renata S. Auriemma, Maria Luisa Appetecchia, Rosario Pivonello, Giovanna Mantovani, Andrea M. Isidori, Marie‐Lise Jaffrain‐Rea, Ashley Grossman, Emilia Sbardella   +17 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, Volume 7, Issue 3, Page 109-124, September 2026.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing

BMC Medical Genetics, 2017
Background Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary.
Bo-Young Kim, Mi-Hyun Park, Hae-Mi Woo, Hye-Yeong Jo, Ji Hoon Kim, Hyung Jin Choi, Soo Kyung Koo   +6 more
doaj   +1 more source

Genetic and Epigenetic Analysis in Korean Patients with Multiple Endocrine Neoplasia Type 1 [PDF]

Endocrinology and Metabolism, 2014
BackgroundMultiple endocrine neoplasia type 1 (MEN1) is a familial syndrome characterized by the parathyroid, pancreas and pituitary tumors. Parathyroid tumors are the most common clinical manifestations, occurring in more than 90% of MEN1 patients ...
Yoon Jung Chung, Sena Hwang, Jong Ju Jeong, Sun Yong Song, Se Hoon Kim, Yumie Rhee   +5 more
doaj   +1 more source

Insulinoma Associated with MEN1 Syndrome: A Case of Persistent Hypoglycemia in a School-aged Child

Insulinoma is a rare cause of non-ketotic hypoglycemia, both in adults and in children. Pediatric patients account for approximately 5% of all cases, mostly due to isolated benign lesions, but insulinoma may also be part of a multiple endocrine neoplasia
Liliana Mejía-Zapata, Aura María Salazar-Solarte, Rodrigo Lemus-Zepeda, Diana Marcela Vasquez-Forero, Mario Jr. Angulo-Mosquera   +4 more
core   +1 more source

A MEN1 syndrome with a paraganglioma.

, 2014
International audienceGermline mutations of the MEN1 gene cause multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder characterized by tumors of the parathyroids, the pancreas, and the anterior pituitary.
Stéphanie Lopez, Marie-Pierre Teissier, Stéphanie, Lopez, Manuela Delage-Corre, Jamilloux, Yvan, Morgane Pertuit, Anne Barlier, Françoise Archambeaud, Pertuit, Morgane, Barlier, Anne,, Barlier, Anne, A., Muriel Mathonnet, Sophie Galinat, Archambeaud, Françoise, Yvan Jamilloux, Favier, Judith, Judith Favier, Delage-Corre, Manuela, Mathonnet, Muriel, Galinat, Sophie, Teissier, Marie-Pierre   +20 more
core   +1 more source

Pituitary Neuroendocrine Tumors in Multiple Endocrine Neoplasia [PDF]

Endocrinology and Metabolism
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant disorder characterized by tumors of the pituitary, parathyroid, and endocrine-gastrointestinal tract. Pituitary neuroendocrine tumors (PitNETs) occur in about 40% of MEN1 cases, with 10%
Sang Ouk Chin, Constance Chik, Toru Tateno   +2 more
doaj   +1 more source

Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto, Shunji Takahashi, Shigehisa Kitano   +2 more
wiley   +1 more source

Late onset asymptomatic pancreatic neuroendocrine tumor – A case report on the phenotypic expansion for MEN1

Hereditary Cancer in Clinical Practice, 2017
Background Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome associated with several endocrine as well as non-endocrine tumors and is caused by mutations in the MEN1 gene.
Charu Kaiwar, Sarah K. Macklin, Jennifer M. Gass, Jessica Jackson, Eric W. Klee, Stephanie L. Hines, John A. Stauffer, Paldeep S. Atwal   +7 more
doaj   +1 more source

Inter‐tissue relationships of gene expression in liver, muscle and adipose tissue of children with end‐stage chronic liver disease

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 3, Page 500-508, September 2026.
Abstract Objectives End‐stage chronic liver disease in children is associated with sarcopenia and aberrant adipose tissue mass. We investigated correlations between liver pathology‐associated gene pathways (fibrosis, inflammation and steatosis) and metabolic genes in muscle and adipose tissue.
Eirini Kyrana, Cheng Zhang, Han Jin, Siamak Salehi, Jonathan C. K. Wells, Maesha Deheragoda, Ragai R. Mitry, Anil Dhawan   +7 more
wiley   +1 more source