Results 71 to 80 of about 12,302 (171)

Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions

, 2007
BACKGROUND: Patients with a multiple endocrine neoplasia type 1 (MEN1)-associated Zollinger-Ellison syndrome (ZES) show multifocal duodenal gastrinomas and precursor lesions.AIMS: To test these lesions for loss of heterozygosity (LOH) of the MEN1 gene ...
Gimm, O, Komminoth, P, Schmitt, A,, Perren, A,, Henopp, T, Anlauf, M, Weihe, E,, Dralle, H, Perren, Aurel, Knoefel, W T,, Raffel, A, Kloppel, G, Heitz, P. U, Garbrecht, N, Gimm, O,, Anlauf, M,, Rudolf, T,, Garbrecht, N,, Weihe, E, Klöppel, G,, Henopp, T,, Raffel, A,, Schmitt, A, Rudolf, T, Dralle, H,, Knoefel, W T, Heitz, Ph U,, Komminoth, P,   +27 more
core   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source

A rare case of a combination of metabolic and genetic changes in one patient (multiple endocrine neoplasia type 1 syndrome and Williams syndrome)

Ожирение и метаболизм
Asthma and obesity are diseases characterized by variability in the course and possible complications, the frequency of which is steadily increasing from year to year.
E. E. Filkina, E. G. Przhiyalkovskaya, A. A. Lazareva, M. Yu. Yukina   +3 more
doaj   +1 more source

Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival

JCI Insight, 2022
Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome.
Vinod Vijayakurup, Kyungah Maeng, Hye Seung Lee, Benjamin Meyer, Sandra Burkett, Akbar Nawab, Michael W. Dougherty, Christian Jobin, Iqbal Mahmud, Timothy J. Garrett, Michael Feely, Kyoung Bun Lee, Frederic J. Kaye, Maria V. Guijarro, Maria Zajac-Kaye   +14 more
doaj   +1 more source

Dual‐isotope subtraction scintigraphy and SPECT‐CT for preoperative localization of parathyroid adenomas

Clinical Physiology and Functional Imaging, Volume 46, Issue 5, September 2026.
Abstract Context Primary hyperparathyroidism (PHPT) is often caused by a parathyroid adenoma (PTA). Subtraction scintigraphy with 123I and 99mTc –MIBI SPECT‐CT, and neck ultrasound examination as a hybrid scan (HS) can be used to localize the PTA in order to promote minimally invasive surgery.
Patricia M. Udholm, Christian S. Eriksen, Sabrina H. d'Este, Pernille Bach‐Mortensen, Søren Møller   +4 more
wiley   +1 more source

The role of Men1 in pituitary gland tumourigenesis [PDF]

, 2004
Summary The pituitary gland is a key regulator of growth, metabolism and sexual development. The pituitary gland integrates signals from the hypothalamus and from peripheral endocrine glands and responds to changing physiological needs by secreting a ...
Gredsted, Lars
core   +1 more source

Genetic background influences tumour development in heterozygous Men1 knockout mice [PDF]

, 2020
Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder caused by MEN1 germline mutations, is characterised by parathyroid, pancreatic and pituitary tumours. MEN1 mutations also cause familial isolated primary hyperparathyroidism (FIHP)
Christie, Paul T, Mallon, Ann-Marie, Thakker, Rajesh V., Piret, Sian E., Christie, Paul T., Javid, Mahsa, Walls, Gerard, Kooblall, Kreepa G, Piret, Sian E, Stevenson, Mark, Reed, Anita Ac, Simon, Michelle, Newey, Paul J, Walls, Gerard V., Lines, Kate E., Newey, Paul J., Thakker, Rajesh V, Lines, Kate E, Kooblall, Kreepa G.   +18 more
core   +1 more source

Genotype-phenotype correlation in multiple endocrine neoplasia type 1

JCI Insight
BACKGROUND Among patients with multiple endocrine neoplasia type 1 (MEN1), 80% develop duodenopancreatic neuroendocrine tumors (dpNETs), of whom 15%–25% die of metastasis. There is a need to identify biomarkers to predict aggressive disease.
Charlita C. Worthy, Rana Tora, Chandra N. Uttarkar, James M. Welch, Lynn Bliss, Craig Cochran, Anisha Ninan, Sheila Kumar, Stephen Wank, Sungyoung Auh, Lee S. Weinstein, William F. Simonds, Sunita K. Agarwal, Jenny E. Blau, Smita Jha   +14 more
doaj   +1 more source

Ventricular fibrillation triggered by recurrent hypoglycemia in a patient with insulinoma associated with MEN1: case report and review of literature

Endocrine Journal
This report describes the case of a 44-year-old woman without structural heart disease who developed ventricular fibrillation (VF) during preoperative management of multiple pancreatic neuroendocrine tumors (NETs) associated with multiple endocrine ...
Kotaro Doi, Shin Kaneko, Yoshikuni Asami, Amane Yamamoto, Takeshi Kano, Yoshikuni Kawaguchi, Kiyoshi Hasegwa, Masafumi Kaiume, Toshiko Kobori, Maki Takeuchi, Junichiro Sato, Midori Fujisihro, Masaomi Nangaku, Noriko Makita   +13 more
doaj   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source