Results 111 to 120 of about 616,871 (170)

Discovery and preclinical activity of the menin-KMT2A inhibitor ziftomenib in acute leukemia models.

Blood
Miao H, Wu T, Purohit T, Chen D, Klossowski S, Borkin D, Clegg B, Ray J, Park S, Stevens R, Kim E, Kempinska K, Wang Y, He M, Wen B, Goldman JW, Agrusa J, Ding C, Sulis ML, Sun D, Mody R, Kim AS, Ren P, Li LS, Liu Y, Burrows F, Kessler L, Cierpicki T, Grembecka J.   +28 more
europepmc   +1 more source

Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study. [PDF]

Hematol Oncol
Batayneh O, Danziger N, Moein M, Naji NS, Pavlick D, Ross JS, Marcus C, Ho C, Gentile T, Zhou Z, Pasquina LW.   +10 more
europepmc   +1 more source

The tumor suppressor menin is a key scaffold mediator for homologous recombination repair. [PDF]

Nucleic Acids Res
Lian A, Zhu X, Jin B, Gu G, Xu B, Zhang L, Lin X, Zhu X, Jin G.   +8 more
europepmc   +1 more source

Introduzione. La filosofia del «promeneur solitaire»

, 2017
Marco Menin, Lorenzo Rustighi
core  

Wired to Survive: How AML Cytogenetics Shape Apoptotic Dependence and Venetoclax Resistance. [PDF]

Genes (Basel)
Rojas A, Jethi S, Budak-Alpdogan T, Pandey MK.   +3 more
europepmc   +1 more source

Identification and Management of Differentiation Syndrome in Emergency Settings: A Narrative Review. [PDF]

Cancers (Basel)
Chang GA, Bey T, Stroh J, Qdaisat A, Yeung SJ.   +4 more
europepmc   +1 more source

Targeted Therapy in Acute Myeloid Leukemia: Current Approaches and Novel Directions. [PDF]

J Pers Med
Ko KH, Gelfer R, Wheat JC, Cai SF.
europepmc   +1 more source

The role of menin inhibitors in acute myeloid leukemia

Current Opinion in Oncology
Purpose of review Acute myeloid leukemia (AML) characterized by NPM1 mutations or KMT2A rearrangements depends on abnormal epigenetic programs mediated by menin, a critical scaffold protein for sustaining the expression of oncogenic HOX/MEIS1 genes. Therefore, menin inhibitors have become a promising class of AML treatments.
Isidori A., Marconi G.
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Menin Inhibitor Induced Menin Protein Degradation Contributes to Menin Inhibitor Efficacy

Blood, 2023
The chromatin adaptor protein Menin ( MEN1) is necessary for sustained proliferation in acute leukemias driven either by Lysine Methyltransferase 2A (MLL1/ KMT2A) gene rearrangements. Small molecule Menin inhibitors (MIs) disrupt the MENIN-KMT2A protein interaction by competing with KMT2A for a binding pocket in Menin.
Jevon Cutler, Jonathan Tsai, Brandon Regalado, Wallace Bourgeois, Daniela Wenge, Jeonghyeon Kim, Radoslaw Nowak, Elizabeth Ener, Katherine Donovan, Sarah Naomi Olsen, Eric Fischer, Benjamin L. Ebert, Scott A Armstrong   +12 more
openaire   +1 more source