Results 41 to 50 of about 616,871 (170)

Research Advances on Menin Inhibitors in Treatment of Acute Myeloid Leukemia

Zhongliu Fangzhi Yanjiu
Acute myeloid leukemia (AML) is characterized by marked biological heterogeneity, and molecular classification is essential for therapeutic decision-making and prognostic stratification.
Shuai SU, Yi XIAO
doaj   +1 more source

Combination Strategies with Menin Inhibitors for Acute Leukemia

Blood Cancer Discovery
Abstract Menin inhibitors are targeted therapies for the treatment of genetically defined subsets of acute leukemia. The menin inhibitor revumenib is approved for the treatment of relapsed or refractory leukemia with rearrangement of KMT2A.
Ghayas C. Issa, Sheng F. Cai, Alex Bataller, Hagop M. Kantarjian, Eytan M. Stein   +4 more
openaire   +2 more sources

Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations [PDF]

Chromosomal translocations of the nucleoporin 98 (NUP98) gene are found in acute myeloid leukemia (AML) patients leading to very poor outcomes. The oncogenic activity of NUP98 fusion proteins is dependent on the interaction between Mixed Lineage Leukemia
Grembecka, Jolanta, Chen, Dong, Ferrando, Adolfo, Miao, Hongzhi, Ropa, James, Kim, EunGi, Purohit, Trupta, Cierpicki, Tomasz, Sulis, Maria-Luisa   +8 more
core   +1 more source

Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies

Biomarker Research
Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates.
Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi, Mitra Zabihi, Sahar Parkhideh, Mohammad Hossein Mohammadi   +5 more
doaj   +1 more source

Designed to Kill: Novel Menin-MLL Inhibitors Target MLL-Rearranged Leukemia [PDF]

, 2015
The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity.
Armstrong, Scott A., Kühn, Michael W.M.   +1 more
core   +1 more source

Efficacy and Potential Limitation of the Menin Inhibitor Revumenib Outside Clinical Trials: Extramedullary Response with Central Nervous System Escape in a Case of KMT2A-Rearranged Acute Myeloid Leukemia

Targets
Acute myeloid leukemia (AML) harboring KMT2A rearrangements (KMT2A-r) accounts for approximately 5–10% of newly diagnosed cases and represents a high-risk AML subtype associated with poor clinical outcomes despite intensive treatment strategies ...
Martina Canichella, Cristina Papayannidis, Mariagiovanna Cefalo, Carla Mazzone, Valentina Gianfelici, Luca Cupelli, Jacopo Nanni, Iole Cordone, Francesco Marchesi, Antonio Spadea, Paolo de Fabritiis, Maria Ilaria Del Principe   +11 more
doaj   +1 more source

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.

, 2005
Mutations in the MEN1 gene are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), which is characterized by parathyroid hyperplasia and tumors of the pituitary and pancreatic islets.
Dou, Y, Milne, TA, Hess, JL, Rozenblatt-Rosen, O, Krankel, C, Schnepp, RW, Livolsi, VA, Hughes, CM, Gibbs, D, Hua, X, Yang, Z, Milne, Thomas, Meyerson, M, Roeder, RG, Lloyd, R   +14 more
core   +1 more source

Structure-Based Discovery of M‑89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein–Protein Interaction

, 2019
Inhibition of the menin-mixed lineage leukemia (MLL) protein–protein interaction is a promising new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein our structure-based design, synthesis, and
Denzil Bernard (1348401), James Delproposto (843775), Donna McEachern (573068), Krishnapriya Chinnaswamy (843776), Caroline Foster (5851562), Angelo Aguilar (573070), Kaitlin P. Harvey (6867059), Shilin Xu (1884217), Jeff W. Kampf (1537393), Liu Liu (512237), Shaomeng Wang (88290), Ester Fernandez-Salas (3860806), Jeanne Stuckey (1334310), Tianfeng Xu (1884211), Ke Zheng (119395), Liyue Huang (797169)   +15 more
core   +2 more sources

Meccanismi, emozioni, incendi

, 2014
Il pensiero metateatrale di Roland Schimmelpfennig nell'indagine della modernità come rimozizone del ...
MENIN, ROBERTO
core   +1 more source

Menin-driven mTOR signaling sustains taxane resistance in CRPC and reveals a targetable vulnerability for combination therapy

Cell Communication and Signaling
Prostate cancer (PC) progression is predominantly driven by androgen signaling, making androgen deprivation therapy (ADT) the standard treatment. However, the transition to castration-resistant prostate cancer (CRPC) significantly reduces ADT efficacy ...
Ipek Bulut, Buse Cevatemre, Neslihan Yuksel-Catal, Hamzah Syed, Tamer Onder, Ceyda Acilan   +5 more
doaj   +1 more source