Results 71 to 80 of about 616,871 (170)

Regulation of HOX gene expression in AML

Blood Cancer Journal
As key developmental regulators, HOX cluster genes have varied and context-specific roles in normal and malignant hematopoiesis. A complex interaction of transcription factors, epigenetic regulators, long non-coding RNAs and chromatin structural changes ...
Irum Khan, Mohammed A. Amin, Elizabeth A. Eklund, Andrei L. Gartel   +3 more
doaj   +1 more source

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

, 2015
The protein–protein interaction (PPI) between menin and mixed lineage leukemia (MLL) plays a critical role in acute leukemias, and inhibition of this interaction represents a new potential therapeutic strategy for MLL leukemias.
Sunil Kumar Upadhyay (1309560), Timothy J. Senter (1309548), Trupta Purohit (1309551), Craig W. Lindsley (203380), Shaun R. Stauffer (1309554), Shihan He (1309557), Jolanta Grembecka (474873), Changho Han (1309563), Rocco D. Gogliotti (416216), Jonathan Pollock (1309566), Tomasz Cierpicki (236778)   +10 more
core   +1 more source

Current status and research directions in acute myeloid leukemia

Blood Cancer Journal
The understanding of the molecular pathobiology of acute myeloid leukemia (AML) has spurred the identification of therapeutic targets and the development of corresponding novel targeted therapies.
Hagop Kantarjian, Gautam Borthakur, Naval Daver, Courtney D. DiNardo, Ghayas Issa, Elias Jabbour, Tapan Kadia, Koji Sasaki, Nicholas J. Short, Musa Yilmaz, Farhad Ravandi   +10 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer
Background Nucleophosmin (NPM1), a multifunctional nucleolar protein, plays critical roles in ribosome biogenesis, chromatin organization, and genome stability.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
doaj   +1 more source

Taking the direct route: menin inhibitors go straight to the frontline in KMT2A-rearranged acute leukemia.

Menin inhibitors disrupt oncogenic transcription in KMT2A-rearranged leukemias, but responses are heterogeneous. A previous study highlighted the role of nongenetic resistance driven by altered chromatin context, including loss of KMT2C/D-UTX activity ...

core   +2 more sources

A Practical Alternative to Refine the Estimate of fmCYP3A4 and Evaluate Drug–Drug Interaction Potential for Ziftomenib Using PBPK Modeling to Inform Labeling

CPT: Pharmacometrics & Systems Pharmacology
Accurate physiologically based pharmacokinetic (PBPK) simulation of drug–drug interaction (DDI) potential requires estimation of the relative contribution of the impacted pathway.
Ian E. Templeton, Chara Litou, Hannah M. Jones, Julie Mackey Ahsan, Marilyn Tabachri, Mollie Leoni, Amitava Mitra   +6 more
doaj   +1 more source

Targeting Menin in Acute Myeloid Leukemia: Therapeutic Advances and Future Directions

Germline mutations in the MEN1 gene encoding menin protein cause multiple endocrine neoplasia type 1 (MEN1) syndrome. Recent evidence suggests that inhibiting the interaction of menin with its crucial oncogenic protein partners represents a promising ...
Vikram Dhillon, Suresh Kumar Balasubramanian, Sandhya Dhiman   +2 more
core   +1 more source

«Marco Menin, Il sole nero dei Lumi. Sade filosofo» [PDF]

Il volume è volto a meglio presentare Sade filosofo al fine di ricontestualizzarlo nella corrente dei Lumi a cui, malgrado la persistenza di molteplici pregiudizi storiografici – la svalutazione della sua riflessione teorico-filosofica in nome di un ...
Paola Perazzolo
core   +1 more source

Menin in Cancer

The protein menin is encoded by the MEN1 gene and primarily serves as a nuclear scaffold protein, regulating gene expression through its interaction with and regulation of chromatin modifiers and transcription factors.
Xianxin Hua, Ariana D. Majer, Bryson W. Katona   +2 more
core   +1 more source

Menin inhibitors as a treatment for acute leukemia: from bench to the clinic. [PDF]

Blood Neoplasia
Watts J, Madarang E, Cierpicki T, Grembecka J.   +3 more
europepmc   +1 more source