Results 181 to 190 of about 42,235 (304)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 58-72, January 2026.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, Volume 36, Issue 1, January 2026.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source

Clinicoradiologic Correlation in Bilateral Internuclear Ophthalmoplegia Revealing a Ruptured Pontine Abscess. [PDF]

Cureus
Mebrouk Y, Mabrouki FE.
europepmc   +1 more source

Investigation of Prognostic Factors in Patients With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

European Journal of Neurology, Volume 33, Issue 1, January 2026.
This graphical abstract shows GFAP‐IgG detection using tissue‐based and cell‐based assays (top). It illustrates the selection of patients for comparing favorable and unfavorable prognosis groups (bottom left). Finally, it presents multiple regression analysis results identifying predictors of poor prognosis 6 months after admission (bottom right ...
Akio Kimura, Akira Takekoshi, Yoichi Maekawa, Keiko Tanaka, Yoshihisa Yamano, Kuniaki Saito, Masao Takemura, Takayoshi Shimohata   +7 more
wiley   +1 more source

T cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges. [PDF]

J Clin Invest
Sharma ND, Keewan E, Ornatowski W, Paul S, Nysus M, Barnett CC, Wolfson J, Jacquez Q, Myers BL, Kang H, Zychowski KE, Winter SS, Loh ML, Hunger SP, Castillo EF, Taghon T, Halsey C, Vue TY, Jones N, Ntziachristos P, Matlawska-Wasowska K.   +20 more
europepmc   +1 more source

Recent developments in eosinophilic renal neoplasms: what's new, true and important?

Histopathology, Volume 88, Issue 1, Page 166-192, January 2026.
Recent developments and acquired knowledge on newer renal entities with eosinophilic cytoplasm opened insights into the clinical, pathological, immunohistochemical, molecular, epidemiological aspects, and the prognosis of these entities. We emphasize the role of routine morphology, aided by appropriate and select immunohistochemistry, as essential keys
Kiril Trpkov, Farshid Siadat, Rola Saleeb   +2 more
wiley   +1 more source

An Imitation Too Perfect: Isolated Neurosarcoidosis Mimicking Spheno-Orbital Meningioma With Hyperostosis. [PDF]

Cureus
Finet P, Daoud L, Desclée P.
europepmc   +1 more source

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

B cell treatments for multiple sclerosis [PDF]

, 2017
McLauchlan, Duncan, Robertson, Neil P.
core   +1 more source

Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo. [PDF]

Commun Biol
Roberts LM, Hammel JH, Jin P, Cunningham JJ, Schumaecker S, Davis S, Azar F, Feng TA, Wang M, Rutkowski M, Munson J.   +10 more
europepmc   +1 more source