Results 131 to 140 of about 1,340,233 (253)

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 251-268, December 2025.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Metagenomic next‐generation sequencing provides a rapid and accurate diagnosis of pathogens in patients undergoing immunosuppressive therapy

Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Metagenomics next‐generation sequencing is superior to that of conventional methods for the diagnosis of infections in patients treated with immunosuppressants. Blood samples could be used for rapid diagnosis of suspected viral infection, and samples from infectious sites have significant advantages in detecting bacterial and viral co‐infection ...
Lei Yue, Mengjiao Yuan, Chang Li, Miaomiao Zhang, Mengjia Qian, Qi Shen, Lingyan Wang, Yanxia Zhan, Bijun Zhu, Yujie Zhou, Hao Chen, Guoming Shi, Yunfeng Cheng   +12 more
wiley   +1 more source

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source

Next‐Generation Sequencing in Infectious‐Disease Diagnostics: Economic, Regulatory, and Clinical Pathways to Adoption

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Next‐generation sequencing (NGS) is poised to transform infectious‐disease diagnostics. Falling per‐sample costs, new CPT codes and FDA pathways, and 24‐h, multiplexed resistome reports converge to deliver faster, evidence‐based therapy and stronger surveillance. Our roadmap links the economic, regulatory, and clinical pillars to accelerate routine NGS
John Osei Sekyere
wiley   +1 more source

Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant Clostridium tertium Strain

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The comparative genomic analysis provides information about how C. tertium HGMC01 strain cause disease through mucin glycan degradation, colonization, multidrug resistance, and modulation of immune responses. Moreover, this analysis data suggest that this strain interacts with host cells by degrading mucin in the gut, potentially through recognition or
Seonghun Kim, Ji Young Kang, Jung‐Sook Lee   +2 more
wiley   +1 more source

Infectious Triggers and Immune Dynamics in Guillain–Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Aswathi Ramesh, Rajasekaran Subbarayan, Dhasarathdev Srinivasan, Ranjith Balakrishnan, Rupendra Shrestha, Ankush Chauhan   +5 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Vancomycin‐Modified DNA Origami Nanostructures for Targeting Bacterial Pathogens

Small Structures, Volume 6, Issue 12, December 2025.
Applications of DNA origami nanostructures in pathogen detection and antimicrobial drug delivery require their efficient and robust binding to bacterial cells. Here, the cell wall‐binding glycopeptide antibiotic vancomycin is conjugated to selected staple strands and displayed in multivalent arrangements on the DNA origami surface to facilitate the ...
Özge Coşkuner Leineweber, Bhanu K. Pothineni, Nils Schumann, Ulrike Hofmann, Christin Möser, David M. Smith, Guido Grundmeier, Yixin Zhang, Adrian Keller   +8 more
wiley   +1 more source

Awareness of Microbiological Safety in Playgrounds Amid Rising Antibiotic Resistance

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Playgrounds are identified as reservoirs for antibiotic‐resistant bacteria, posing a potential public health risk. Despite the existence of safety regulations for playground equipment, microbiological safety is treated superficially. Global strategies, including hygiene practices and antibacterial materials, are needed to reduce the spread of ...
Rafał Łopucki, Marcin Skowronek, Anna Bilokinna, Guillermo Martinez‐de‐Tejada, Ilona Sadok   +4 more
wiley   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source