BACKGROUND The MenAfriNet Consortium supports strategic implementation of case-based meningitis surveillance in key high-risk countries of the African meningitis belt: Burkina Faso, Chad, Mali, Niger, and Togo.
Heidi M. Soeters +21 more
semanticscholar +1 more source
Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis [PDF]
Background: Cronobacter sakazakii and C. malonaticus can cause serious diseases especially in infants where they are associated with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis.
A Lehner +57 more
core +2 more sources
A Systematic Review of Cases of Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis on Lumbar Puncture [PDF]
Background: Definitive diagnosis of meningitis is made by analysis of cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR) obtained from a lumbar puncture (LP), which may take days.
Pettigrew, Alexis, Troendle, Michelle
core +1 more source
Effect of case management on neonatal mortality due to sepsis and pneumonia. [PDF]
BACKGROUND: Each year almost one million newborns die from infections, mostly in low-income countries. Timely case management would save many lives but the relative mortality effect of varying strategies is unknown.
Bhutta, Zulfiqar A +7 more
core +1 more source
Targeting the complement system in bacterial meningitis
Morbidity and mortality in bacterial meningitis are driven by an uncontrolled host inflammatory response. Koelman et al. evaluate the detrimental role of the complement system in spurring this inflammation, and conclude that anaphylatoxin C5a is a ...
D. Koelman, M. Brouwer, D. van de Beek
semanticscholar +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011. [PDF]
BackgroundSince the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years.
Bennett, Nancy +15 more
core +1 more source
Key Points Question Are febrile neonates (in the first month of life) at higher risk for bacteremia and bacterial meningitis than febrile infants in their second month of life?
E. Biondi +6 more
semanticscholar +1 more source
Smart Sampling Capsule for Capture and Detection of Enteric Pathogens in the Small Intestine
An ingestible smart sampling capsule for capturing asymptomatic enteric pathogens at their primary sites of interaction within the small intestine. This capability enables non‐invasive detection of early pathogen colonization within the gut environment prior to fecal shedding, providing a robust approach for pathogen surveillance and microbiome studies.
Akshay Krishnakumar +6 more
wiley +1 more source
Community-acquired Bacterial Meningitis in Adults With Cerebrospinal Fluid Leakage
Background Cerebrospinal fluid (CSF) leakage is a risk factor for developing bacterial meningitis. Methods We analyzed episodes of community-acquired bacterial meningitis associated with CSF leakage from a prospective nationwide cohort study. Results CSF
Liora Ter Horst +3 more
semanticscholar +1 more source

