Results 41 to 50 of about 81,347 (234)

Bacterial meningitis in Africa

Frontiers in Neurology, 2023
Bacterial meningitis differs globally, and the incidence and case fatality rates vary by region, country, pathogen, and age group; being a life-threatening disease with a high case fatality rate and long-term complications in low-income countries. Africa has the most significant prevalence of bacterial meningitis illness, and the outbreaks typically ...
Tatiana Barichello, Tatiana Barichello, Carlos Henrique Rocha Catalão, Carlos Henrique Rocha Catalão, Ursula K. Rohlwink, Ursula K. Rohlwink, Ursula K. Rohlwink, Martijn van der Kuip, Dan Zaharie, Dan Zaharie, Regan S. Solomons, Ronald van Toorn, Marceline Tutu van Furth, Rodrigo Hasbun, Federico Iovino, Vivian Ssonko Namale, Vivian Ssonko Namale   +16 more
openaire   +3 more sources

BacSafe: A Comprehensive Database for Integrated Assessment of Bacterial Biosafety

iMetaMed, EarlyView.
The substantial threats that bacterial contamination poses to healthcare and industrial production requires a comprehensive assessment of biosafety risks for each bacterial species. Here, we introduce BacSafe, a novel database that integrates diverse domains of biosafety knowledge and evaluates bacterial risk across both clinical and environmental ...
Ye Feng, Chengzhi Liu, Qian Liang, Lupeng Ma, Weilian Chen, Fanyuan Gu, Biao Tang, Zhijian Wang, Guoping Zhao, Huan Chen   +9 more
wiley   +1 more source

Validation of multiplex PCR for the diagnosis of acute bacterial meningitis in culture negative cerebrospinal fluid

Arquivos de Neuro-Psiquiatria, 2019
This study evaluated the operational characteristics of the multiplex polymerase chain reaction (PCR) for cerebrospinal fluid (CSF) from patients with cellular and biochemical characteristics of acute bacterial meningitis and positive or negative CSF ...
Sérgio Monteiro de Almeida, Libera Maria Dalla Costa, Christian Siebra, Lavinia Nery Villa Stangler Arend, Keite da Silva Nogueira   +4 more
doaj   +1 more source

Risk Factors and Comorbidity in Patients with Bacterial Meningitis

Acta Medica Bulgarica, 2023
Introduction. Bacterial meningitis is a severe disease with high mortality and frequent residual neurological sequelae. It is associated with multiple risk factors.
Argirova P., Kalchev Y., Murdjeva M., Stoycheva M.   +3 more
doaj   +1 more source

Evaluation of Ceftriaxone as a Monotherapy and Amoxicillin With Clavulanic Acid as Combination Therapy in Surgical Prophylaxis

iNew Medicine, EarlyView.
ABSTRACT Surgical antibiotic prophylaxis (SAP) is crucial in preventing postoperative surgical site infections (SSIs), especially in clean and clean‐contaminated surgeries. It was a prospective comparative observational study that compared the effectiveness and safety of single‐dose ceftriaxone monotherapy with amoxicillin–clavulanic acid as a ...
Anayat Ullah, Arsh Ali, Md Nematullah, Suriya Kumar Singh, Anant Singh Paliwal, Najish Parveen   +5 more
wiley   +1 more source

Comparison of enterovirus detection in cerebrospinal fluid with Bacterial Meningitis Score in children

Einstein (São Paulo)
Objective To measure the role of enterovirus detection in cerebrospinal fluid compared with the Bacterial Meningitis Score in children with meningitis. Methods A retrospective cohort based on analysis of medical records of pediatric patients diagnosed
Frederico Ribeiro Pires, Andréia Christine Bonotto Farias Franco, Alfredo Elias Gilio, Eduardo Juan Troster   +3 more
doaj   +1 more source

A Diagnostic Formula for Discrimination of Tuberculous and Bacterial Meningitis Using Clinical and Laboratory Features

Frontiers in Cellular and Infection Microbiology, 2020
Background: The discrimination of tuberculous meningitis and bacterial meningitis remains difficult at present, even with the introduction of advanced diagnostic tools.
Yun Yang, Xin-Hui Qu, Kun-Nan Zhang, Xiao-Mu Wu, Xin-Rong Wang, An Wen, Ling-Juan Li   +6 more
doaj   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children

Nature Communications
Invasive pneumococcal disease (IPD) due to non-vaccine serotypes after the introduction of pneumococcal conjugate vaccines (PCV) remains a global concern.
Cebile Lekhuleni, Kedibone Ndlangisa, Rebecca A. Gladstone, Sopio Chochua, Benjamin J. Metcalf, Yuan Li, Jackie Kleynhans, Linda de Gouveia, Scott Hazelhurst, Ana D. S. Ferreira, Happy Skosana, Sibongile Walaza, Vanessa Quan, Susan Meiring, Paulina A. Hawkins, Lesley McGee, Stephen D. Bentley, Cheryl Cohen, Stephanie W. Lo, Anne von Gottberg, Mignon du Plessis   +20 more
doaj   +1 more source