Results 41 to 50 of about 1,340,233 (253)

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

open access: yesAdvanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera   +12 more
wiley   +1 more source

HUBUNGAN ANTARA TINGKAT KESADARAN DENGAN ANGKA KEMATIAN PADA PENDERITA MENINGITIS BAKTERI AKUT DI RSU HAJI SURABAYA PERIODE JANUARI 2006 ­DESEMBER 2009 [PDF]

open access: yes, 2010
Background: Acute bacterial meningitis is one disease of causing a high level of mortality and morbidity rate, in Indonesia. Objective: To identify the relationship between consciousness level and mortality rate on patients of acute bacterial ...
ANITA, NIA
core  

Multilocus sequence typing of Cronobacter spp. from powdered infant formula and milk powder production factories [PDF]

open access: yes, 2013
This study applied the Cronobacter spp. multilocus sequence typing (MLST) scheme to three strain collections, then known as Enterobacter sakazakii, which had been isolated between 1988 and 2009 from 14 countries. The results revealed the predominance (85%
Craven, HM   +4 more
core   +1 more source

Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

open access: yesNature Communications, 2019
Bacterial mutations predisposing pneumococcus to causing meningitis, a more severe form of invasive pneumococcal disease (IPD), are largely unknown.
Yuan Li   +10 more
semanticscholar   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

open access: yesAdvanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang   +9 more
wiley   +1 more source

Mechanisms of Brain Injury in Bacterial Meningitis: Workshop Summary [PDF]

open access: yes, 2017
Morbidity and mortality associated with bacterial meningitis remain high, although antibiotic therapy has improved during recent decades. The major intracranial complications of bacterial meningitis are cerebrovascular arterial and venous involvement ...
Fontana, Adriano   +4 more
core  

The Infectious Disease Ontology in the Age of COVID-19 [PDF]

open access: yes, 2021
The Infectious Disease Ontology (IDO) is a suite of interoperable ontology modules that aims to provide coverage of all aspects of the infectious disease domain, including biomedical research, clinical care, and public health.
Babcock, Shane   +3 more
core   +1 more source

Bacterial Meningitis in Infants

open access: yesClinics in Perinatology, 2015
Neonatal bacterial meningitis is an uncommon but devastating infection. Although the incidence and mortality have declined over the last several decades, morbidity among survivors remains high. The types and distribution of causative pathogens are related to birth gestational age, postnatal age, and geographic region.
Lawrence C, Ku   +2 more
openaire   +3 more sources

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

open access: yesAdvanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li   +7 more
wiley   +1 more source

Mathematical Modelling of Bacterial Meningitis Transmission Dynamics with Control Measures

open access: yesComput. Math. Methods Medicine, 2018
Vaccination and treatment are the most effective ways of controlling the transmission of most infectious diseases. While vaccination helps susceptible individuals to build either a long-term immunity or short-term immunity, treatment reduces the number ...
Joshua Kiddy K. Asamoah   +4 more
semanticscholar   +1 more source

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