Results 51 to 60 of about 1,340,233 (253)

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Vancomycin‐Functionalized Nanodelivery Systems for Antibacterial Tissue Engineering Scaffolds

Advanced NanoBiomed Research, EarlyView.
This review consolidates recent advancements in VAN nanoformulations, critically evaluating their design principles, release mechanisms, and efficacy profiles against resistant Gram‐positive pathogens. While promising in vitro and in vivo results have been demonstrated, the clinicaltranslation of these technologies necessitates further rigorous ...
Nima Beheshtizadeh, Mahsa Mohammadzadeh, Amir Abbas Seraji, Ali Pirsadeghi, Elham Zendedel, Maliheh Gharibshahian   +5 more
wiley   +1 more source

Pediatric Bacterial Meningitis Surveillance in the World Health Organization African Region Using the Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2011–2016

Clinical Infectious Diseases, 2019
Background Bacterial meningitis is a major cause of morbidity and mortality in sub-Saharan Africa. We analyzed data from the World Health Organization’s (WHO) Invasive Bacterial Vaccine-preventable Diseases Surveillance Network (2011–2016) to describe ...
J. Mwenda, E. Soda, G. Weldegebriel, R. Katsande, J. Biey, T. Traore, L. De Gouveia, M. du Plessis, A. von Gottberg, M. Antonio, B. Kwambana-Adams, A. Worwui, R. Gierke, Stephanie B. Schwartz, C. V. Van Beneden, A. Cohen, F. Serhan, F. Lessa   +17 more
semanticscholar   +1 more source

Neurological Complications in Young Infants With Acute Bacterial Meningitis

Frontiers in Neurology, 2018
We aimed to evaluate the occurrence, treatment, and outcomes of neurological complications after bacterial meningitis in young infants. A case series study from a retrospective cohort from two tertiary-level medical centers in Taiwan between 2007 and ...
M. Hsu, J. Hsu, H. Kuo, Mei-Yin Lai, M. Chiang, Ying-Jui Lin, Hsuan‐Rong Huang, S. Chu, Ming-Horng Tsai   +8 more
semanticscholar   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Matrix Metalloproteinase-9 in Pneumococcal Meningitis: Activation via an Oxidative Pathway [PDF]

, 2017
In experimental bacterial meningitis, matrix metalloproteinases (MMPs) and reactive oxygen species (ROS) contribute to brain damage. MMP-9 increases in cerebrospinal fluid (CSF) during bacterial meningitis and is associated with the brain damage that is ...
Christen, Stephan, Leib, Stephen L., Meli, Damian N.   +2 more
core  

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

Loop-Mediated Isothermal Amplification Methods for Diagnosis of Bacterial Meningitis

Frontiers in Pediatrics, 2018
The rapid, accurate, and efficient identification of an infectious disease is critical to ensure timely clinical treatment and prevention in public health settings.
M. Seki, P. Kilgore, E. J. Kim, M. Ohnishi, S. Hayakawa, D. W. Kim   +5 more
semanticscholar   +1 more source

Chemical Composition, Antioxidant, and Antibacterial Activities of Mezilaurus duckei (Lauraceae)

Chemistry &Biodiversity, EarlyView.
ABSTRACT Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves. Chemical profiling
Bruna S. Moroto, Valéria S. Gonçalves, David J. Machate, Talita V. Freire, Érica L. Santos, Flávio M. Alves, Ana C. Micheletti, Nídia C. Yoshida   +7 more
wiley   +1 more source

Lack of continuity between Cronobacter biotypes and species as determined using multilocus sequence typing [PDF]

, 2013
The accuracy of the Cronobacter biotyping scheme was compared with the 7-loci multilocus sequence typing scheme. Biotyping did not reliably assign species level identification, as only half (17/31) of the biotype variants were unique to any of the seven ...
Baldwin, Cruz, Farmer, Francisco, Hariri, Hochel, Iversen, Iversen, Iversen, Iversen, Joseph, Joseph, Joseph, Joseph, Joseph, Karamonová, Stephen J. Forsythe, Sumyya Hariri, Susan Joseph, Turcovsky   +19 more
core   +1 more source