The role of plasminogen activator inhibitor-2 in pneumococcal meningitis
Acta Neuropathologica Communications, 2022 Pneumococcal meningitis is associated with dysregulation of the coagulation cascade. Previously, we detected upregulation of cerebral plasminogen activator inhibitor-2 (PAI-2) mRNA expression during pneumococcal meningitis.
Nina C. Teske +8 more
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Meningococcal and pneumococcal meningitis in Northern Ghana [PDF]
, 2008 Despite improvements in technology, treatments and understanding of how bacterial meningitis develops, the disease remains a potentially life-threatening emergency capable of causing significant morbidity and mortality. N. meningitidis, S.
Forgor, Abdulai Adams
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Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. [PDF]
, 2009 During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages.
Häcker Georg +20 more
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Pneumococcal Meningitis in Adults after Introduction of PCV7 and PCV13, Israel, July 2009–June 2015
Emerging Infectious Diseases, 2018 The indirect effect of pneumococcal conjugate vaccine on adult pneumococcal meningitis has not been thoroughly investigated. We present data from active surveillance on pneumococcal meningitis in adults in Israel occurring during July 2009–June 2015 ...
Gili Regev-Yochay +10 more
doaj +1 more source
Emerging Infectious Diseases, 2019 We describe the effects of the 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccines on pneumococcal meningitis in England and Wales during July 1, 2000–June 30, 2016.
Godwin Oligbu +8 more
doaj +1 more source
Trends in Pneumococcal and Bacterial Meningitis in Brazil from 2007 to 2019
Vaccines, 2023 The pneumococcal conjugate vaccination (PCV) was introduced into the Brazilian Childhood National Immunization Program in 2010; however, universal pneumococcal vaccination for older adults has not been implemented yet.
Cintia Irene Parellada +8 more
doaj +1 more source
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
PLoS ONE, 2014 We previously identified CCL20 as an early chemokine in the cerebrospinal fluid (CSF) of patients with pneumococcal meningitis but its functional relevance was unknown.
Matthias Klein +13 more
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Microbiology Spectrum, 2022 Streptococcus pneumoniae is one of the leading causes of meningitis in children. In Japan, since the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), the number of pneumococcal meningitis due to non-PCV13 serotypes in children has ...
Erika Kurihara +6 more
doaj +1 more source
Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]
, 2010 INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna +51 more
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Pneumococcal antibody concentrations and carriage of pneumococci more than 3 years after infant immunization with a pneumococcal conjugate vaccine. [PDF]
, 2012 BACKGROUND: A 9-valent pneumococcal conjugate vaccine (PCV-9), given in a 3-dose schedule, protected Gambian children against pneumococcal disease and reduced nasopharyngeal carriage of pneumococci of vaccine serotypes.
Greenwood, Brian M +31 more
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