Results 61 to 70 of about 380,344 (356)

Assessment of acute headache in adults - what the general physician needs to know. [PDF]

, 2018
Headache is common. Up to 5% of attendances to emergency departments and acute medical units are due to headache. Headache is classified as either primary (eg migraine, cluster headache) or secondary to another cause (eg meningitis, subarachnoid ...
Agrawal, Cappelen-Smith, Dodick, Hoffmann, Mac Grory, Macdonald, omi, Savitz, Sheikh, Solomon   +9 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Smart Sampling Capsule for Capture and Detection of Enteric Pathogens in the Small Intestine

Advanced Materials Technologies, EarlyView.
An ingestible smart sampling capsule for capturing asymptomatic enteric pathogens at their primary sites of interaction within the small intestine. This capability enables non‐invasive detection of early pathogen colonization within the gut environment prior to fecal shedding, providing a robust approach for pathogen surveillance and microbiome studies.
Akshay Krishnakumar, Devendra Sarnaik, Nicholas L. F. Gallina, Robyn R. McCain, Christa Crain, Arun K. Bhunia, Rahim Rahimi   +6 more
wiley   +1 more source

Molecular characterization of invasive meningococcal isolates in Burkina Faso as the relative importance of serogroups X and W increases, 2008–2012

BMC Infectious Diseases, 2018
Background Neisseria meningitidis serogroup A disease in Burkina Faso has greatly decreased following introduction of a meningococcal A conjugate vaccine in 2010, yet other serogroups continue to pose a risk of life-threatening disease. Capsule switching
Adam C. Retchless, Malika Congo-Ouédraogo, Dinanibè Kambiré, Jeni Vuong, Alex Chen, Fang Hu, Absetou Ky Ba, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Jaymin C. Patel, Rasmata Ouédraogo Traoré, Lassana Sangaré, Xin Wang   +12 more
doaj   +1 more source

Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant

Nature Communications, 2023
Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike protein alone. Here we report on the isolation of the live BA.2.86 subvariant from a diagnostic swab collected in South Africa
Khadija Khan, Gila Lustig, Cornelius Römer, Kajal Reedoy, Zesuliwe Jule, Farina Karim, Yashica Ganga, Mallory Bernstein, Zainab Baig, Laurelle Jackson, Boitshoko Mahlangu, Anele Mnguni, Ayanda Nzimande, Nadine Stock, Dikeledi Kekana, Buhle Ntozini, Cindy van Deventer, Terry Marshall, Nithendra Manickchund, Bernadett I. Gosnell, Richard J. Lessells, Quarraisha Abdool Karim, Salim S. Abdool Karim, Mahomed-Yunus S. Moosa, Tulio de Oliveira, Anne von Gottberg, Nicole Wolter, Richard A. Neher, Alex Sigal   +28 more
doaj   +1 more source

Salmonella Infection After Craniotomy. [PDF]

, 2017
Salmonella is an uncommon cause of meningitis, especially after neurosurgery. Here, we present a case of Salmonella meningitis after craniotomy, likely due to physical contact with a snake after surgery, with contiguous spread from the patient's hand to ...
Byer, Lennox, Jacobs, Richard, Osorio, Joseph A, Rutledge, Caleb, Theodosopoulos, Philip V, Wallender, Erika   +5 more
core  

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A, Akinsola, Bolanle, Baldeh, Ignatius, Greenwood, Brian M, Hill, Philip C, Howie, Stephen RC, Ikumapayi, Usman N, Jasseh, Momodou, Knoll, Maria Deloria, Lee, Ellen, Levine, Orin S, Mackenzie, Grant A, Plumb, Ian D, Saha, Debasish, Sambou, Sana, Touray, Kebba, Uchendu, Uchendu, Usuf, Effua, Wattiaux, Andre   +18 more
core   +2 more sources

Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury

Advanced Science, EarlyView.
This study investigates the mechanism of succinate dehydrogenase (SDH)‐mediated succinate oxidation in microglia extracellular traps (MiETs) formation and neuronal injury after cerebra I/R injury. Dimethyl malonate (DMM), a competitive SDH inhibitor, could reduce MiETosis by inhibiting succinate oxidation and mtROS production during reperfusion ...
Lili Zhao, Tao Li, Meijuan Dang, Ye Li, Jialiang Lu, Ziwei Lu, Zhiyang Chen, Qiao Huang, Yujie Chen, Yang Yang, Yuxuan Feng, Xiaoya Wang, Yating Jian, Heying Wang, Yingying Guo, Lei Zhang, Yu Jiang, Songhua Fan, Shengxi Wu, Hong Fan, Fang Kuang, Guilian Zhang   +21 more
wiley   +1 more source

Dynamic Profiling of Lipoteichoic Acid (LTA) and/or Lipopolysaccharide (LPS) Positive Extracellular Vesicles in Plasma as Diagnostic and Prognostic Biomarkers for Bacterial Infection

Advanced Science, EarlyView.
Using nano‐flow cytometry, this study analyzes the dynamic characteristics of lipoteichoic acid (LTA) and/or lipopolysaccharide (LPS) positive extracellular vesicles in the bloodstream of patients with bacterial infections, providing promising biomarkers for rapid and accurate diagnosis.
Qianqian Gao, Wenwu Zhou, Nadira Nurxat, Ke Xu, Yunyun Xu, Wei Li, Tianchi Chen, Cong Hu, Liang Dong, Qian Liu, Min Li   +10 more
wiley   +1 more source

Synthesis, Conformal Analysis, and Antibody Binding of Staphylococcus aureus Capsular Polysaccharide Type 5 Oligosaccharides

Angewandte Chemie, EarlyView.
A set of conjugation‐ready Staphylococcus aureus serotype 5 oligosaccharides has been generated using a stereoselective [3 + 3n] glycosylation strategy. The structures differ in chain length (up to three repeating units) and O‐ and N‐acetylation pattern.
Kitt E. Østerlid, Sizhe Li, Luca Unione, Linda Del Bino, Charlotte Sorieul, Filippo Carboni, Francesca Berni, Sara Bertuzzi, Bob van Puffelen, Ana Arda, Herman S. Overkleeft, Gijsbert A. van der Marel, Maria Rosaria Romano, Jesús Jiménez‐Barbero, Roberto Adamo, Jeroen D. C. Codée   +15 more
wiley   +2 more sources