Results 61 to 70 of about 15,719 (229)

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody, binds properdin and albumin and is being developed to treat complement‐mediated diseases.
Avner Sandhu, Tong Shen, Paz Martin Herrero, Chao‐Xing Yuan, Samirah Qureshi, Xiaoyu Jiang, Ye Sheng, Christoph Gasteyger, Yang Dai   +8 more
wiley   +1 more source

2024 update on meningococcal vaccination recommendations for children and adults

Pediatria Polska
The best protection against invasive infections caused by meningococcus (Neisseria meningitidis), which can lead to death or permanent disability, is immunization.
Ernest Kuchar, Hanna Czajka, Ewelina Gowin, Maria Katarzyna Borszewska-Kornacka, Aneta Nitsch-Osuch, Anna Skoczyńska, Leszek Szenborn, August Wrotek, Jacek Wysocki, Agnieszka Mastalerz-Migas, Jarosław Peregud-Pogorzelski, Teresa Jackowska   +11 more
doaj   +1 more source

Long‐Term Efficacy and Safety of Ravulizumab in Adults With Anti‐Acetylcholine Receptor Antibody‐Positive Generalized Myasthenia Gravis: Final Results From the Phase 3 CHAMPION MG Open‐Label Extension

European Journal of Neurology, Volume 32, Issue 4, April 2025.
Ravulizumab demonstrated clinically meaningful and durable efficacy and safety in adults with anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis in the CHAMPION MG open‐label extension (OLE) study. Improvements from baseline in MG‐ADL, QMG, and MG‐QOL15r total scores, and the NeuroQOL Fatigue subscale scores achieved in ...
Tuan H. Vu, Renato Mantegazza, Djillali Annane, Masahisa Katsuno, Andreas Meisel, Michael W. Nicolle, Vera Bril, Rasha Aguzzi, Glen Frick, James F. Howard Jr, the CHAMPION MG Study Group   +10 more
wiley   +1 more source

Meningococcaemia causing necrotizing cellulitis associated with acquired complement deficiency after gastric bypass surgery: a case report

BMC Infectious Diseases, 2020
Background Neisseria meningitidis has rarely been described as an agent of necrotic soft tissue infection. Case presentation We report a case of a septic shock with necrotizing cellulitis due to Neisseria meningitidis serogroup W, treated by urgent ...
Zoe Pletschette, Elodie De Groote, Wesley Mattheus, Charlotte Waxweiler, Jacques Creteur, David Grimaldi   +5 more
doaj   +1 more source

Meningococcal antigen in diagnosis and treatment of group A meningococcal infections

The American Journal of Medicine, 1975
Meningococcal antigen was measured by countercurrent immunoelectrophoresis in the blood and cerebrospinal fluid of 200 patients with group A meningococcal meningitis. Antigen was detected in the blood of 27 (13.5 per cent) patients. These patients had a worse prognosis and a higher incidence of allergic complications, such as arthritis and vasculitis ...
Whittle, H, Greenwood, B, Davidson, N, Tomkins, A, Tugwell, P, Warrell, D, Zalin, A, Bryceson, A, Parry, E, Brueton, M, Duggan, M, Oomen, J, Rajkovic, A   +12 more
openaire   +3 more sources

Invasive meningococcal disease

Arquivos de Neuro-Psiquiatria, 2013
Invasive meningococcal disease (IMD) is a major public health and continues to cause substantial mortality and morbidity. Serotype C is the most frequent in Brazil.
Vanessa L. Strelow, Jose E. Vidal
doaj   +1 more source

Serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y concordancia con la cepa de la vacuna cubana Meningococcus B serosubtypes causing invasive disease in Cantabria [Spain] and agreement with the Cuban vaccine strain

Gaceta Sanitaria, 2004
Objetivo: Conocer los serosubtipos de meningococo B causantes de enfermedad invasiva en Cantabria y el porcentaje de concordancia con la cepa de la vacuna cubana VA-Mengoc-BC.
Álvaro González de Aledo, Luis Viloria
doaj  

Meningococcal vaccination in pregnancy

Human Vaccines & Immunotherapeutics, 2018
Invasive meningococcal disease causes meningitis and septicemia worldwide with highest rates of disease occurring in children
Bahaa Abu Raya, Manish Sadarangani
doaj   +1 more source

Epidemiology of Meningococcal Disease, New York City, 1989–2000

Emerging Infectious Diseases, 2003
Study of the epidemiologic trends in meningococcal disease is important in understanding infection dynamics and developing timely and appropriate public health interventions.
Alexandre Sampaio Moura, Ariel Pablos-Méndez, Marcelle Layton, Don Weiss   +3 more
doaj   +1 more source

STUDIES ON MENINGOCOCCAL INFECTION [PDF]

, 1942
Arthur E.O. Menzel, Geoffrey Rake
openalex   +1 more source