Results 1 to 10 of about 1,596,236 (204)

M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

Frontiers in Psychiatry, 2021
Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~5-AChR) antagonist, has rapid and robust antidepressant effects in humans and other species. However, which of the five M-AChRs mediates these therapeutic effects has not been
Shuang Liu, Dandan Shi, Zuoli Sun, Yi He, Jian Yang, Jian Yang, Gang Wang, Gang Wang   +7 more
doaj   +1 more source

Associations of Neurocognition and Social Cognition With Brain Structure and Function in Early-Onset Schizophrenia

Frontiers in Psychiatry, 2022
BackgroundCognitive impairment is a core feature of schizophrenia that is more serious in patients with early-onset schizophrenia (EOS). However, the neuroimaging basis of cognitive functions, including neurocognition and social cognition, remains ...
Pengfei Guo, Shuwen Hu, Xiaolu Jiang, Hongyu Zheng, Daming Mo, Xiaomei Cao, Jiajia Zhu, Hui Zhong, Hui Zhong   +8 more
doaj   +1 more source

Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation

International Journal of Bipolar Disorders, 2021
Background Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs).
Helle Østergaard Madsen, Shakoor Ba-Ali, Steffen Heegaard, Ida Hageman, Ulla Knorr, Henrik Lund-Andersen, Klaus Martiny, Lars Vedel Kessing   +7 more
doaj   +1 more source

The synergistic effect of depression and moderate chronic kidney disease on the all-cause and cardiovascular disease mortality among adults: a retrospective cohort study

BMC Nephrology, 2022
Background The relationship between the coexistence of depression and moderate chronic kidney disease (CKD) and mortality is unclear. We aimed to investigate whether there is a synergistic effect of depression and moderate CKD on the all-cause and ...
Fanchao Meng, Yanjie Qi, Xu Chen, Xiuping Yan, Huanhuan Huang, Fan He   +5 more
doaj   +1 more source

Neuroanatomical basis of harm avoidance personality traits in major depressive disorder

Journal of Affective Disorders Reports, 2021
Background: : Behavioral inhibition, referred to as the harm avoidance (HA) trait, has been deemed a vulnerability factor for major depressive disorder (MDD).
Yukihito Yomogida, Miho Ota, Junko Matsuo, Ikki Ishida, Shinsuke Hidese, Toshiya Teraishi, Noriko Sato, Hiroshi Matsuda, Kotaro Hattori, Hiroshi Kunugi   +9 more
doaj   +1 more source

Case report: cognitive performance in an extreme case of anorexia nervosa with a body mass index of 7.7

BMC Psychiatry, 2020
Background Studies show that adult patients with anorexia nervosa display cognitive impairments. These impairments may be caused by illness-related circumstances such as low weight.
Simone Daugaard Hemmingsen, Mia Beck Lichtenstein, Alia Arif Hussain, Jan Magnus Sjögren, René Klinkby Støving   +4 more
doaj   +1 more source

Relationship between Interpersonal Sensitivity Measure score and clinical symptoms in patients with major psychiatric disorders and healthy individuals

PCN Reports, 2022
Aim We compared the Interpersonal Sensitivity Measure (IPSM) scores between diagnostic groups and examined the relationship between IPSM scores and clinical variables.
Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yuuki Yokota, Miho Ota, Kotaro Hattori, Hiroshi Kunugi   +6 more
doaj   +1 more source

The increase of PTSD in front-line health care workers during the COVID-19 pandemic and the mediating role of risk perception: a one-year follow-up study

Translational Psychiatry, 2022
The long-term health consequences of the COVID-19 pandemic on health care workers (HCWs) are largely unclear. The purpose of the present study was to investigate the development of posttraumatic stress disorder (PTSD) in HCWs in a longitudinal manner ...
Hui Ouyang, Shiyu Geng, Yaoguang Zhou, Jing Wang, Jingye Zhan, Zhilei Shang, Yanpu Jia, Wenjie Yan, Yan Zhang, Xu Li, Weizhi Liu   +10 more
doaj   +1 more source

Mental health in UK Biobank - development, implementation and results from an online questionnaire completed by 157 366 participants: a reanalysis [PDF]

, 2020
Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for UK Biobank participants to expand its potential.
Adams, M., Allen, N., Breen, G., Coleman, J. R. I., Cullen, B., Davis, K. A. S., Dickens, C., Fox, E., Graham, N., Holliday, J., Hotopf, M., Howard, L. M., John, A., Lee, W., McCabe, R., McIntosh, A., Pearsall, R., Smith, D. J., Sudlow, C., Ward, J., Zammit, S.   +20 more
core   +8 more sources

Mental disorders, brain disorders and values [PDF]

Frontiers in Psychology, 2014
The debates about the normativity of mental disorders and about the distinction between somatic and mental disorders have long been closely linked. This is very obvious in Szasz, who claims that there can only be brain disorders, no mental disorders and that so-called mental disorders are really problems in living.
Anneli eJefferson, Anneli eJefferson
openaire   +5 more sources