Results 101 to 110 of about 4,816,387 (353)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

Trajectories and predictors of suicidal ideation in clinical characteristics and pharmacological treatments for major depressive disorder: a study based on a national multi-centered prospective cohort

open access: yesTranslational Psychiatry
Suicidal ideation (SI) is a significant precursor and risk marker for suicide behaviors in major depressive disorder (MDD). Exploration of SI trajectory from a longitudinal framework are essential for treatment guidelines and clinical management of ...
Ruoxi Ding   +6 more
doaj   +1 more source

Effect of group exercise therapy on improving sleep quality in patients with mild to moderate depressive disorder during the acute phase

open access: yesSichuan jingshen weisheng
BackgroundPatients with depressive disorder commonly experience sleep disturbances. Previous studies have indicated that group exercise therapy is beneficial in alleviating depressive symptom among patients with depressive disorder.
Li Ruinan   +6 more
doaj   +1 more source

All for One and One for All: Mental Disorders in One Dimension.

open access: yesAmerican Journal of Psychiatry, 2018
In both child and adult psychiatry, empirical evidence has now accrued to suggest that a single dimension is able to measure a person's liability to mental disorder, comorbidity among disorders, persistence of disorders over time, and severity of ...
A. Caspi, T. Moffitt
semanticscholar   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

open access: yesAdvanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja   +6 more
wiley   +1 more source

Six-Month Prevalence of Mental Disorders and Service Contacts among Children and Youth in Ontario: Evidence from the 2014 Ontario Child Health Study

open access: yesCanadian journal of psychiatry. Revue canadienne de psychiatrie, 2019
Objectives: To present the 6-month prevalence and sociodemographic correlates of mental disorders and mental health–related service contacts in a sample of children (4 to 11 years) and youth (12 to 17 years) in Ontario.
Katholiki Georgiades   +4 more
semanticscholar   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

open access: yesAdvanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll   +16 more
wiley   +1 more source

Perception of inpatients following remission of a manic episode in bipolar I disorder on a group-based Psychoeducation program: a qualitative study

open access: yesBMC Psychiatry, 2018
Background This forms the first study of a group-based psychoeducation program for inpatients following remission of a manic episode in patients suffering from bipolar I disorder in a Chinese population.
Runsen Chen   +5 more
doaj   +1 more source

Inorganic Dielectric Materials Coupling Micro‐/Nanoarchitectures for State‐of‐the‐Art Biomechanical‐to‐Electrical Energy Conversion Devices

open access: yesAdvanced Materials, EarlyView.
Biomechanical‐to‐electrical energy conversion devices are uniquely suited for self‐driven physiological information monitoring and powering human–computer interaction systems. These devices based on micro‐/nanoarchitectured inorganic dielectric materials (MNIDMs) have shown ultrahigh electromechanical performance and thus great potential for practical ...
Jia‐Han Zhang   +12 more
wiley   +1 more source

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