Results 41 to 50 of about 874,743 (311)

Scopolamine augmentation of a newly initiated escitalopram treatment for major depressive disorder: study protocol for a randomized controlled trial

Trials, 2019
Background Major depressive disorder (MDD) is a prevalent and disabling disorder that can lead to heavy individual, familial, and societal burdens. Although pharmaceutical interventions still play an essential role in therapeutic measures, limitations ...
Jingjing Zhou, Weiwei Wang, Jian Yang, Xuequan Zhu, Lei Feng, Le Xiao, Gang Wang   +6 more
doaj   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Sociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study

International Journal of Bipolar Disorders
Background Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics.
Jin-jie Xu, Xue-quan Zhu, Shuang Liu, Lu-yu Ding, Bing-bing Fu, Cong-cong Sun, Yan-li Pan, Wei Wang, Ling Zhang   +8 more
doaj   +1 more source

Impact of childhood maltreatment on adult resilience

BMC Psychiatry, 2023
Background Previous studies suggested that childhood maltreatment is associated with poor health outcomes. While not everyone who experiences abuse as a child goes on to experience poor mental health, some traumatized people are grown to be more ...
Chao Li, Guanyi Lv, Bangshan Liu, Yumeng Ju, Mi Wang, Qiangli Dong, Jinrong Sun, Xiaowen Lu, Liang Zhang, Ping Wan, Hua Guo, Futao Zhao, Mei Liao, Yan Zhang, Lingjiang Li, Jin Liu   +15 more
doaj   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Factors associated with the frequency of manic and depressive episodes in bipolar disorder: a multicenter study in China

BMC Psychiatry
Background Mania and depression are the predominant mood episodes in bipolar disorder (BD), and their frequency significantly affects the long-term prognosis of patients. Method This is a multicenter, longitudinal cohort study in China.
Shuang Liu, Jin-Jie Xu, Xue-Quan Zhu, Bing-Bing Fu, Yan-Li Pan, Cong-Cong Sun, Sheng Li, Gao-Ming Xie, Ling Zhang   +8 more
doaj   +1 more source

CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani, Tsuyoshi Nakai, Yasuhiro Maeda, Reiko Ohdake, Atsuhiro Higashi, Toshiki Maeda, Ryunosuke Nagao, Sayuri Shima, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Hirohisa Watanabe   +11 more
wiley   +1 more source

Clinical characteristics of 217 Chinese cases with depersonalization/derealization disorder

BMC Psychiatry
Depersonalization/derealization disorder (DPD) is a prevalent yet inadequately understood clinical condition characterized by a recurrent or persistent sense of unreality.
Mingkang Song, Sisi Zheng, Nan Song, Hong Zhu, Yuan Jia, Zhiqing Dai, Xinzi Liu, Ziyao Wu, Yuhang Duan, Zhiyuan Huang, Jindong Chen, Hongxiao Jia   +11 more
doaj   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source

Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger patients

BMC Psychiatry
Background Major depressive disorder (MDD) is a leading contributor to the global disease burden, with suicide constituting a critical complication. Current clinical assessment tools are limited by subjectivity and diagnostic delays, highlighting the ...
Anqi Zhang, Yuncong Qin, Han Wang, Nan Lyu, Qian Zhao, Ling Zhang, Juan Huang   +6 more
doaj   +1 more source