Results 41 to 50 of about 5,076,978 (312)

Nationwide Characterization of MFN2‐Related CMT in 176 Japanese Patients: Clinical and Genetic Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential for understanding disease pathogenesis and improved clinical management.
Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Chikashi Yano, Takahiro Hobara, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +13 more
wiley   +1 more source

Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients

BMC Psychiatry
Background Depersonalization-Derealization Disorder (DPRD) presents challenges in understanding its neurobiological underpinnings. Several neuroimaging studies have revealed altered brain function and structure in DPRD. However, the knowledge about large-
Sisi Zheng, Mingkang Song, Nan Song, Hong Zhu, Xue Li, Dongqing Yin, Shanshan Liu, Yan Zhao, Meng Fang, Yanzhe Ning, Hongxiao Jia   +10 more
doaj   +1 more source

Optimization of measurement-based care (OMBC) for depression based on all-round and continuous assessment: rationale and protocol for a multicenter randomized control clinical trial

Trials, 2022
Background Despite the recent findings presenting the benefits of measurement-based care (MBC) compared to treatment as usual (TAU), MBC is still not the standard of care used in clinical settings.
Jingjing Zhou, Xiao Wang, Jian Yang, Xuequan Zhu, Le Xiao, Lei Feng, Gang Wang   +6 more
doaj   +1 more source

Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia—It Is Not Too Late

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Friedreich's ataxia is a multisystem disorder with scoliosis being the most common non‐neurological manifestation. While scoliosis surgery is typically performed in adolescent, ambulatory patients, few data exist on surgical outcomes in patients with advanced disease.
Kathrin Reetz, Stella A. Lischewski, Jörg B. Schulz, Maximilian Praster, Miguel Pishnamaz, on behalf of the FACROSS study group, Imis Dogan, Sandro Romanzetti, Ravi Dadsena, Kerstin Konrad, Thomas Clavel, Vera Jankowski, Joachim Jankowski, Oliver Pabst, Nikolaus Marx, Julia Moellmann, Malte Jacobsen, Katharina Marx‐Schütt, Juergen Dukart, Simon Eickhoff, Ralf‐Dieter Hilgers   +20 more
wiley   +1 more source

Interaction between BDNF Val66Met polymorphism and mismatch negativity for working memory capacity in schizophrenia

Schizophrenia
Both the brain-derived neurotrophic factor (BDNF) valine (Val)/methionine (Met) polymorphism and mismatch negativity (MMN) amplitude are reportedly linked to working memory impairments in schizophrenia.
Wenpeng Hou, Xiangqin Qin, Hang Li, Qi Wang, Yushen Ding, Xiongying Chen, Ru Wang, Fang Dong, Qijing Bo, Xianbin Li, Fuchun Zhou, Chuanyue Wang   +11 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden

BMC Psychiatry
Background Suicide stands as both a primary symptom and the direst outcome of major depressive disorder (MDD). The scarcity of effective treatment strategies makes managing MDD patients with suicide especially challenging.
Han Wang, Nan Lyu, Juan Huang, Bingbing Fu, Lili Shang, Fan Yang, Qian Zhao, Gang Wang   +7 more
doaj   +1 more source

Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu, Talia Robinson, Marina Rodriguez Alonso, Adela Francis Malave, Roos J. Jutten, Michael J. Properzi, Brian C. Healy, Jackson C. Thompson, Grace Del Carmen Montenegro, Emma Thibault, Dana Penney, Randall Davis, Reisa A. Sperling, Kathryn V. Papp, Keith A. Johnson, Julie C. Price, Dorene M. Rentz   +16 more
wiley   +1 more source

Temporal integration window of sensory processing as a neuropsychological marker for clinical high risk of psychosis

Schizophrenia
Early identification of individuals with clinical high risk (CHR) for psychosis relies heavily on subjective assessments, necessitating the exploration of objective markers to enhance diagnostic accuracy.
Shuo Lin, Lu Tian, Wei-hao Tan, Li-na Wang, Wei-gang Pan, Li Li, Yi Liu, Chao-meng Liu, Han Wu, Wen Wang, Wen-qing Jin, Yi-lang Tang, Yan-ping Ren, Xin Ma   +13 more
doaj   +1 more source

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

World Psychiatry, 2020
The nature and prevalence of combinations of mental disorders and their associations with premature mortality have never been reported in a comprehensive way.
O. Plana-Ripoll, K. Musliner, S. Dalsgaard, N. Momen, Nanna Weye, M. Christensen, E. Agerbo, K. Iburg, T. Laursen, P. Mortensen, C. Pedersen, L. Petersen, D. Santomauro, B. Vilhjálmsson, H. Whiteford, J. Mcgrath   +15 more
semanticscholar   +1 more source