Results 41 to 50 of about 4,798,446 (254)

Scopolamine augmentation of a newly initiated escitalopram treatment for major depressive disorder: study protocol for a randomized controlled trial

Trials, 2019
Background Major depressive disorder (MDD) is a prevalent and disabling disorder that can lead to heavy individual, familial, and societal burdens. Although pharmaceutical interventions still play an essential role in therapeutic measures, limitations ...
Jingjing Zhou, Weiwei Wang, Jian Yang, Xuequan Zhu, Lei Feng, Le Xiao, Gang Wang   +6 more
doaj   +1 more source

Shared and unique alterations of large-scale network connectivity in drug-free adolescent-onset and adult-onset major depressive disorder

Translational Psychiatry
Differences in clinical manifestations and biological underpinnings between Major Depressive Disorder (MDD) onset during adolescence and adulthood have been posited in previous studies, implying an influential role of age of onset (AOO) in the clinical ...
Ximan Hou, Rui Liu, Yuan Zhou, Lin Guan, Jingjing Zhou, Jing Liu, Mengqi Liu, Xiaofei Yuan, Yuan Feng, Xu Chen, Aihong Yu   +10 more
doaj   +1 more source

Impact of childhood maltreatment on adult resilience

BMC Psychiatry, 2023
Background Previous studies suggested that childhood maltreatment is associated with poor health outcomes. While not everyone who experiences abuse as a child goes on to experience poor mental health, some traumatized people are grown to be more ...
Chao Li, Guanyi Lv, Bangshan Liu, Yumeng Ju, Mi Wang, Qiangli Dong, Jinrong Sun, Xiaowen Lu, Liang Zhang, Ping Wan, Hua Guo, Futao Zhao, Mei Liao, Yan Zhang, Lingjiang Li, Jin Liu   +15 more
doaj   +1 more source

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population‐based cohort study

World Psychiatry, 2020
The nature and prevalence of combinations of mental disorders and their associations with premature mortality have never been reported in a comprehensive way.
O. Plana-Ripoll, K. Musliner, S. Dalsgaard, N. Momen, Nanna Weye, M. Christensen, E. Agerbo, K. Iburg, T. Laursen, P. Mortensen, C. Pedersen, L. Petersen, D. Santomauro, B. Vilhjálmsson, H. Whiteford, J. Mcgrath   +15 more
semanticscholar   +1 more source

LC–MS/MS quantification of 20(S)-protopanaxadiol in complex biological matrices for bioanalytical method validation and pharmacokinetic analysis

Scientific Reports
20(S)-Protopanaxadiol (PPD) is a saponin derivative of ginsenoside, with more potent biological and pharmacological activities than Rg3 and Rh2. The lack of ionizable centers leads to low mass spectrometry reactions and internal cleavage of three ...
Pengfei Li, Shanshan Liu, Hongyan Zhuang, Mengxi niu, Fei Pan, Nan Wang, Sha Sha, Qian Wang, Jing Wang   +8 more
doaj   +1 more source

Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients

BMC Psychiatry
Background Depersonalization-Derealization Disorder (DPRD) presents challenges in understanding its neurobiological underpinnings. Several neuroimaging studies have revealed altered brain function and structure in DPRD. However, the knowledge about large-
Sisi Zheng, Mingkang Song, Nan Song, Hong Zhu, Xue Li, Dongqing Yin, Shanshan Liu, Yan Zhao, Meng Fang, Yanzhe Ning, Hongxiao Jia   +10 more
doaj   +1 more source

Clinical characteristics of 217 Chinese cases with depersonalization/derealization disorder

BMC Psychiatry
Depersonalization/derealization disorder (DPD) is a prevalent yet inadequately understood clinical condition characterized by a recurrent or persistent sense of unreality.
Mingkang Song, Sisi Zheng, Nan Song, Hong Zhu, Yuan Jia, Zhiqing Dai, Xinzi Liu, Ziyao Wu, Yuhang Duan, Zhiyuan Huang, Jindong Chen, Hongxiao Jia   +11 more
doaj   +1 more source

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Journal of Neuroinflammation, 2022
Major depressive disorder is a highly debilitating psychiatric disorder involving the dysfunction of different cell types in the brain. Microglia are the predominant resident immune cells in the brain and exhibit a critical role in depression.
Haixia Wang, Yi He, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang, Jian Yang   +6 more
doaj   +1 more source

Sociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study

International Journal of Bipolar Disorders
Background Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics.
Jin-jie Xu, Xue-quan Zhu, Shuang Liu, Lu-yu Ding, Bing-bing Fu, Cong-cong Sun, Yan-li Pan, Wei Wang, Ling Zhang   +8 more
doaj   +1 more source

Characteristics and economic burden of patients with somatoform disorders in Chinese general hospitals: a multicenter cross-sectional study

Annals of General Psychiatry, 2023
Background In China, patients with somatoform disorders (SFD) often seek medical treatment repeatedly in outpatient clinics of general hospitals, which increases unreasonable medical expenses. It is imperative to provide early screening to these patients
Xiangyun Yang, Jia Luo, Pengchong Wang, Yue He, Cong Wang, Lijuan Yang, Jing Sun, Zhanjiang Li   +7 more
doaj   +1 more source