Results 61 to 70 of about 914,522 (268)

Investigating seasonal metabolic variations in bipolar disorder: a targeted metabolomics study

BMC Psychiatry
Background Bipolar disorder (BD) is a severe mental illness characterized by seasonal episodes, yet its metabolic basis remains unclear. Methods This study utilized targeted metabolomics to investigate seasonal metabolic changes.
Xue Li, Xinzi Liu, Ziyan Li, Sitong Feng, Sisi Zheng, Hongxiao Jia, Dongqing Yin   +6 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Sex differences in fecal metabolic profiles of major depressive disorder: unveiling sex-specific metabolomic panel

BMC Psychiatry
Background Major depressive disorder (MDD) disproportionately affects women, who exhibit a higher prevalence and greater symptom severity than men. However, sex-specific pathophysiological mechanisms remain poorly understood. Emerging evidence implicates
Siyu Ren, Peilin Qin, Yaping Wang, Zhiyu Li, Zuoli Sun, Gang Wang, Jian Yang   +6 more
doaj   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

Genome-wide association and DNA methylation analyses of SSRI treatment response in major depressive disorder

BMC Psychiatry
Background Selective serotonin reuptake inhibitors (SSRIs) are first-line treatments for major depressive disorder (MDD); however, patient responses vary significantly.
Nan Lyu, Qian Zhao, Dannong Liu, Jingjing Zhou, Xuequan Zhu, Han Qi, Han Wang, Min Liu, Mengping Wei, Chen Zhang, Ling Zhang, Jian Yang, Gang Wang, Mario Juruena, Allan H Young   +14 more
doaj   +1 more source

Study on the application of STEAM education in clinical teaching of psychoneurologic interdisciplinary

Guoji laonian yixue zazhi
With the development of the times, the development of interdisciplinary integration is more and more important, and cultivating high-quality medical talents with interdisciplinary practical ability is an important goal and demand for the development of ...
Li Yan, Wang Xuechu, Li Fengjuan, Zhou Chang, Wang Yue, Dong Kai   +5 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Safety and effectiveness of transcutaneous auricular vagus nerve stimulation on patients with depersonalization-derealization disorder: study protocol for a randomized controlled trial

Trials
Background Depersonalization-derealization disorder (DPD) is a complex psychiatric condition marked by profound and often relentless feelings of detachment from one’s self and surroundings.
Yan Zhao, Sisi Zheng, Hong Zhu, Dongqing Yin, Meng Fang, Hongxiao Jia   +5 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Altered Structure-Function Coupling Associated with Attention Decline in Shift Work Disorder

Nature and Science of Sleep
Ziyao Wu,1,2,* Sitong Feng,1,2,* Kuangshi Li,3,* Linrui Dong,4 Liang Zhang,1,2 Yanzhe Ning,1,2 Dongqing Yin1,2 1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National ...
Wu Z, Feng S, Li K, Dong L, Zhang L, Ning Y, Yin D   +6 more
doaj