Results 101 to 110 of about 2,694,419 (360)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

open access: yesAdvanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou   +10 more
wiley   +1 more source

Stress, Psychological Distress, and Cognitive Coping Strategies in Caregivers of Patients With Depressive Disorders in Pakistan

open access: yesMental Illness
Conclusion: In conclusion, caregivers of patients with mental illness face a complex and challenging journey marked by high levels of stress and psychological distress.
Rabia Khawar   +9 more
doaj   +1 more source

A new nosology of psychosis and the pharmacological basis of affective and negative symptom dimensions in schizophrenia

open access: yesMental Illness, 2010
Although first rank symptoms focus on positive symptoms of psychosis they are shared by a number of psychiatric conditions. The difficulty in differentiating bipolar disorder from schizophrenia with affective features has led to a third category of ...
Costa Vakalopoulos
doaj   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

open access: yesAdvanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai   +12 more
wiley   +1 more source

Diagnostic stability of acute and transient psychotic disorders in developing country settings: an overview

open access: yesMental Illness, 2015
Acute and transient psychotic disorders (ATPD), introduced in the International Classification of Diseases (ICD-10) diagnostic system in 1992, are not receiving much attention in developing countries.
Shubham Mehta
doaj   +1 more source

Can language use in social media help in the treatment of severe mental illness?

open access: green, 2021
Deanna L. Kelly   +5 more
openalex   +2 more sources

Mental illness and suicide among physicians

open access: yesThe Lancet, 2021
S. Harvey   +7 more
semanticscholar   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

open access: yesAdvanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai   +7 more
wiley   +1 more source

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