Results 71 to 80 of about 2,506,985 (266)

Managing Madness: The ethics of identifying and treating mental illness [PDF]

, 2019
This essay analyzes different contemporary models for defining mental illness and offers a new framework that promotes the use of normative values during the clinical diagnostic process.
Seely, Mason
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Transition of care from child to adult mental health services : the great divide [PDF]

, 2009
Purpose of review: Adolescents with mental health problems often require transition of care from child and adolescent to adult mental health services.
Singh, Swaran P.
core   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Effects of motor imagery training on muscle strength and co-contraction for older adults

Frontiers in Psychology
ObjectiveThis pilot study aimed to evaluate the effectiveness of motor imagery training (MIT) in enhancing maximal voluntary contraction (MVC) force among healthy older adults and inducing neural adaptations measured by electromyography (EMG) signals of ...
Wan X. Yao, Bernadett Mamone, Sha Ge, Mehmed B. Bayram, Mehmed B. Bayram, Jiang Wu, Bo Y. Jiang, John Q. Zhang, Guang H. Yue, Guang H. Yue   +9 more
doaj   +1 more source

A review and conceptual re-examination of mental toughness: implications for future researchers [PDF]

, 2008
This paper provides a review of mental toughness research and examines the major conceptual concerns that are evident in current mental toughness literature.
Anisman, Bandura, Bloom, Bloor, Bull, Cattell, Clough, Clow, Connaughton, Crust, Crust, Davis, Dienstbier, Erikson, Fawcett, Fourie, Gibson, Golby, Golby, Golby, Golby, Goldberg, Gordon, Gould, Howe, Johansson, Jones, Jones, Kelly, Kitzinger, Knight, Kobasa, Kobasa, Kroll, Lee Crust, Levy, Loehr, Loehr, Loehr, Maddi, McAuley, Miller, Nesti, Nicholls, Nicholls, Pruessner, Rauste-Von Wright, Roessler, Sheard, Thelwell, Ursin, Vaernes, Wade   +52 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Interrogating the prevention approach of the Housing (Wales) Act 2014 for people with mental health needs who are homeless [PDF]

, 2019
Rates of homelessness and poor mental health present significant challenges across the globe. In this article, we explore how these intersecting issues have been addressed in Wales through Part 2 of the Housing (Wales) Act 2014 through a paradigm shift ...
Andrea Gibbons, Anya Ahmed, Dahlgren, Guy, Iolo Madoc-Jones, Katy Jones, Mackie, MacKie, Maher, Mark Wilding, Michaela Rogers   +10 more
core   +4 more sources