Results 91 to 100 of about 2,900,207 (363)

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Deficiency in Mental Rotation of Upper and Lower-Limbs in Patients With Multiple Sclerosis and Its Relation With Cognitive Functions

Acta Medica Iranica, 2016
Mental rotation is a cognitive motor process which was impaired in different neurologic disorders. We investigated whether there were deficits in response pattern, reaction time and response accuracy rate of mental rotation in multiple sclerosis (MS ...
Mahdieh Azin, Nasser Zangiabadi, Yousef Moghadas Tabrizi, Farhad Iranmanesh, Mohammad Reza Baneshi   +4 more
doaj  

Visual mental imagery during caloric vestibular stimulation. [PDF]

, 2006
We investigated high-resolution mental imagery and mental rotation, while the participants received caloric vestibular stimulation. High-resolution visual mental imagery tasks have been shown to activate early visual cortex, which is deactivated by ...
Kosslyn, S, Mast, F, Merfeld, D
core   +1 more source

Comparison of brain activity between motor imagery and mental rotation of the hand tasks: a functional magnetic resonance imaging study

Brain Imaging and Behavior, 2018
Motor imagery (MI) has been considered effective in learning and practicing movements in many fields. However, when evaluating the effectiveness of this technique, the examiner has no way of assessing the participant’s motor imagery process.
Hiroyuki Hamada, D. Matsuzawa, Chihiro Sutoh, Y. Hirano, Sudesna Chakraborty, Hiroshi Ito, H. Tsuji, T. Obata, E. Shimizu   +8 more
semanticscholar   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Research on catastrophe progression of driving load in mountainous road based on visual and environmental characteristics

Engineering Reports, Volume 5, Issue 1, January 2023., 2023
(1) The study found that the pupil area change rate, heart beat change rate and eyelid closure have good consistency for characterizing the driver's load. (2) In mountainous road, the driving load is different under different alignment conditions. The driving load is the largest when turning left, the second when turning right, and the smallest when ...
Meng Yunwei, Lang Wen, Tangzhi Liu, Jin Xu, Boren Zheng, Xiyan Zhang, Guangyan Qing   +6 more
wiley   +1 more source

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

Advanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang, Hai‐Chao Chen, Jia‐Xin Cao, Si‐Wei Zhou, Yue‐Zhang Ma, Yu‐Hong Jing   +5 more
wiley   +1 more source

Multiple Sampling Capsule Robot for Studying Gut Microbiome

Advanced Intelligent Systems, EarlyView.
A multiple sampling capsule robot (MSCR) is developed for longitudinal gut microbiome analysis. Employing electromagnetic field control, the MSCR can locomote actively, precisely align the selected channel, and collect up to six microbiome samples with minimal cross‐contamination.
Sanghyeon Park, Manh Cuong Hoang, Jayoung Kim, Sukho Park   +3 more
wiley   +1 more source

Deep‐Learning Model for Central Nervous System Infection Diagnosis and Prognosis Using Label‐Free 3D Immune‐Cell Morphology in the Cerebrospinal Fluid

Advanced Intelligent Systems, EarlyView.
Early diagnosis and prognosis prediction of central nervous system infections are critical. This study introduces a deep‐learning model utilizing cerebrospinal fluid immune‐cell morphology captured via 3D holotomography. The model effectively predicts infection etiology and prognosis, achieving high accuracy.
Bo Kyu Choi, Ho Heon Yang, Jong Hyun Kim, JaeSeong Hong, Kyung Min Kim, Yu Rang Park   +5 more
wiley   +1 more source

Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: Evidence from gene expression and behavior symptom analyses

Human Brain Mapping, Volume 44, Issue 1, Page 258-268, January 2023., 2023
The study revealed that the optimal frequency of some resting‐state FCs in ASD was higher than that in HCs. The gene expression and clinical symptom evidence showed that the FC optimal frequency difference of ASD/HCs is related to social communication deficits in ASD.
Jinjin Long, Fengmei Lu, Shanshan Yang, Qianyue Zhang, Xue Chen, Yajing Pang, Min Wang, Bifang He, Heng Liu, Xujun Duan, Huafu Chen, Shaobing Ye, Heng Chen   +12 more
wiley   +1 more source