Results 101 to 110 of about 2,887,223 (392)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Gender and sexual orientation differences in cognition across adulthood : age is kinder to women than to men regardless of sexual orientation [PDF]

, 2007
Despite some evidence of greater age-related deterioration of the brain in males than in females, gender differences in rates of cognitive aging have proved inconsistent.
A. E. Grulich, A. Herlitz, A. Herlitz, A. L. Benton, A. Lacreuse, A. Lacreuse, B. Hommel, C. A. Depp, C. Adams-Price, C. Brayne, C. E. Coffey, C. M. De Frias, C. R. De Luca, D. F. Halpern, D. F. Halpern, D. Julien, D. Kimura, E. Barrett-Connor, E. J. Meinz, E. M. Zelinski, Elizabeth A. Maylor, G. Der, G. J. Larrabee, G. J. Larrabee, H. L. Hawkins, H. Ryan, I. Silverman, Irwin Silverman, J. C. Pruessner, J. Cerella, J. Cohen, J. D. Sinnott, J. E. Yonker, J. S. Meyer, Jean Choi, K. O. McGraw, K. R. Allen, K. W. Schaie, L. Drabble, L. Ellis, L. Ellis, L. Hayflick, L. L. Barnes, M. Diehl, M. F. Elias, M. H. Birnbaum, M. J. Aartsen, M. King, M. L. Collaer, M. Lövdén, M. Peters, Marcia L. Collaer, Michael Peters, N. Dickson, N. Raz, N. Selwyn, P. E. Cowell, P. Rabbitt, P. Rabbitt, Q. Rahman, Q. Rahman, Q. Rahman, R. A. Dixon, R. de Graaf, R. W. Robins, R. W. Woodcock, S. Berg, S. D. Cochran, S. D. Gosling, S. J. Cutler, S. LeVay, S. P. Springer, S. Reimers, S. T. Stewart, Stian Reimers, T. A. Salthouse, T. A. Salthouse, T. A. Salthouse, T. Buchanan, T. G. M. Sandfort, T. Singer, T. T. Perls, T. T. Perls, U.-D. Reips, W. C. Wiederholt   +84 more
core   +1 more source

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer

Advanced Science, EarlyView.
PAD1 is upregulated within the CD133+ subset or cisplatin‐resistant ovarian cancer cells, which is positively associated with the upregulation of stemness‐related markers and maintenance of stemness in OCSLCs. Mechanistically, PAD1‐catalyzed AKT2 citrullination at R202 facilitates AKT2 phosphorylation, promoting CEBPβ expression and its binding to the ...
Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei, Jian Gu, Yun Han, Jia Xing, Xiaohan Liu, Fei Liang, Paul R Thompson, Xuesen Zhang   +10 more
wiley   +1 more source

The admission experience survey italian version (I-AES). a factor analytic study on a sample of 156 acute psychiatric in-patients [PDF]

, 2019
Coercive treatments are often regarded as an inevitable and yet highly debated feature of psychiatric care. Perceived coercion is often reported by patients involuntarily committed as well as their voluntary counterparts. The Admission Experience Survey (
Biondi, Massimo, Ferracuti, Stefano, Mandarelli, Gabriele, Parmigiani, Giovanna, Roma, Paolo, Tessari, Gianmarco, Trobia, Federico   +6 more
core   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Preference for Male Facial Masculinity as a Function of Mental Rotation Ability in Gay and Bisexual Men, but Not in Heterosexual Men and Women in China

Frontiers in Psychology, 2019
This study examined the association between mental rotation ability and facial masculinity preference in gay and bisexual men in China. The participants (436 gay/bisexual men, 132 heterosexual men, and 254 heterosexual women) completed an online Shepard ...
Lijun Zheng
doaj   +1 more source

Bridging the Gap: Enhancing Modern Anatomy Education Through Mental Rotation Training and 3D Technological Integration

West Kazakhstan Medical Journal, 2023
Mental rotation is a crucial cognitive skill for understanding spatial relationships and three-dimensional aspects, especially in the study of anatomy.
Reza Shirazi, Shabnam Bakhshalizadeh
doaj   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Dedifferentiation and Transfer in Executive Function and Math Ability Following a Five‐Year Abacus Training in Schoolchildren

Advanced Science, EarlyView.
While cognitive development typically exhibits differentiation, marked by decreasing inter‐domain correlations, this study demonstrates that five‐year abacus training is associated with de‐differentiation of executive function and mathematical ability in school‐aged children.
Tianyong Xu, Xinyang Liu, Hongjian He, Changsong Zhou, Andrea Hildebrandt, Feiyan Chen   +5 more
wiley   +1 more source

Biological mechanism of sex differences in mental rotation: Evidence from multimodal MRI, transcriptomic and receptor/transporter data

NeuroImage
Sex differences in mental rotation are a well-documented phenomenon in cognitive research, with implications for the differing prevalence of neuropsychiatric disorders such as autism spectrum disorder (ASD), Alzheimer's disease (AD) and major depressive ...
Haixia Long, Hao Wu, Chaoliang Sun, Xinli Xu, Xu-Hua Yang, Jie Xiao, Mingqi Lv, Qiuju Chen, Ming Fan   +8 more
doaj   +1 more source