Results 41 to 50 of about 77,193 (258)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The role of rotational hand movements and general motor ability in children’s mental rotation performance

Frontiers in Psychology, 2015
Mental rotation of visual images of body parts and abstract shapes can be influenced by simultaneous motor activity. Children in particular seem to have a strong coupling between motor and cognitive processes.
Petra eJansen, Jan eKellner
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

No role of working memory in the relation between mental rotation and postural stability

Frontiers in Cognition
This study investigated the relationship between mental rotation ability and postural stability, with a focus on the role of the visuospatial sketchpad of working memory, as it has been found to be correlated with both concepts.
Philipp Hofmann, Markus Siebertz, Petra Jansen   +2 more
doaj   +1 more source

Interfacial Acid Sites‐Mediated ZnO‐Based Electrocatalysts for Sustainable Dual‐Pathway H2O2 Production and Rechargeable Zn‐H2O2 Electrochemical Cell

Advanced Materials, EarlyView.
In this work, a synergistic strategy introduces interfacial acid sites, oxygen vacancies, and built‐in electric field into ZnSe/ZnO heterojunction to optimize its electronic structure and electrode micro‐environment. This overcomes sluggish oxygen reduction reaction kinetics and low H2O2 selectivity, achieving record H2O2 productivity (754.4 M gcat−1 ...
Lijun Yang, Sitong Liu, Wencheng He, Fengzhan Sun, Shubing Bi, Hongge Pan, Lingfeng Zhu, Tianyi Ma, Lei Zhang   +8 more
wiley   +1 more source

Echinoderm‐Inspired Autonomy for Soft‐Legged Robots

Advanced Robotics Research, EarlyView.
Inspired by echinoderms, a modular soft robot achieves autonomous phototaxis without a central controller or explicit communication. Each limb independently adapts its actuation timing through local sensing and short‐term memory. Coordination emerges purely from physical interactions, demonstrating resilience to changes in morphology, environment, and ...
Harmannus A. H. Schomaker, Jelle de Vries, Johannes T. B. overvelde   +2 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Deficiency in Mental Rotation of Upper and Lower-Limbs in Patients With Multiple Sclerosis and Its Relation With Cognitive Functions

Acta Medica Iranica, 2016
Mental rotation is a cognitive motor process which was impaired in different neurologic disorders. We investigated whether there were deficits in response pattern, reaction time and response accuracy rate of mental rotation in multiple sclerosis (MS ...
Mahdieh Azin, Nasser Zangiabadi, Yousef Moghadas Tabrizi, Farhad Iranmanesh, Mohammad Reza Baneshi   +4 more
doaj  

Variation in Performance Strategies of a Hand Mental Rotation Task on Elderly

Frontiers in Human Neuroscience, 2019
A hand mental rotation task (HMRT) is a task wherein a person judges whether an image of a rotated hand is of the right or left hand. Two performance strategies are expected to come into play when performing these tasks: a visual imagery (VI) strategy ...
Izumi Nagashima, Kotaro Takeda, Nobuaki Shimoda, Yusuke Harada, Hideki Mochizuki   +4 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source