Results 61 to 70 of about 9,274 (253)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Seeing like private security: Evolving mentalities of public space protection in South Africa

open access: yes, 2010
This article will illustrate, by means of three empirical research examples conducted in South Africa, that private security operating in public spaces simultaneously retains ‘traditional’ private security mentalities of loss prevention as well as ...
Julie Berg, Berg, Julie
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Onomástica y mentalidades en el siglo XVI

open access: yesEspacio, Tiempo y Forma. Serie IV, Historia Moderna, 2004
Este artículo pretende señalar que la Onomástica, entendida como un sistema simbólico, puede ser una vía de aproximación a la Historia de las Mentalidades.
José Antonio Ballesteros Díez
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

G. E. R. Lloyd, Demystifying Mentalities

open access: yes, 1993
Jorion Paul. G. E. R. Lloyd, Demystifying Mentalities. In: L'Homme, 1993, tome 33 n°125. pp.
Jorion, Paul
core  

Tolerancia religiosa romana e intolerancia cristiana en los templos del Alto-Egipto: Raíces y huellas

open access: yesGerión, 2008
The title of this paper condenses one of the characteristics that the late religious fact adopted: as opposed to the tolerance that in general characterized the ancient pagan cults, the Christianity adopted during and after the fourth century the form of
José Ramón Aja Sánchez
doaj  

The Philosophy of War and Peace [PDF]

open access: yesФилософия и космология, 2016
In the paper the author comprehends ontology of the war and peace. Using the results of empirical and theoretical research in the field of geophilosophy, as well as neuroscience, psychology, social philosophy and military history, the author comprehends ...
Oleg Bazaluk, Tamara Blazhevych
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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