Results 181 to 190 of about 10,503 (191)
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Mepolizumab for the treatment of eosinophilic granulomatosis with polyangiitis
Expert Opinion on Biological Therapy, 2019Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by asthma, hypereosinophilia, and progressive multiorgan involvement. Although not fully elucidated, advancement in our understanding of the pathophysiology of EGPA has led to the development of multiple new ...
Jason Kihyuk Lee+2 more
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Mepolizumab-responsive Kimura disease
The Journal of Allergy and Clinical Immunology: In Practice, 2021Manao Kinoshita+4 more
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Mepolizumab-based therapy in asthma
Current Opinion in Allergy & Clinical Immunology, 2015There is considerable evidence that implicates eosinophils as important effector cells in the inflammation characteristic of eosinophilic asthma. IL-5 is central to eosinophil maturation and release from the bone marrow, their subsequent accumulation, activation and persistence in the tissues.
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Mepolizumab for the treatment of eosinophilic granulomatosis with polyangiitis
Drugs of Today, 2018Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare but potentially life-threatening antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis which affects, to varying degrees, the lungs, paranasal sinuses, heart, kidneys, skin and peripheral nervous system. It is strongly associated with asthma. Peripheral eosinophilia is a defining
Claire McBrien, Andrew Menzies-Gow
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Mepolizumab for the treatment of severe eosinophilic asthma
American Journal of Health-System Pharmacy, 2017Published data on the pharmacology, pharmacokinetics and pharmacodynamics, and clinical efficacy and safety of the interleukin-5 antagonist mepolizumab are reviewed.Asthma of the eosinophilic phenotype is characterized by persistent eosinophilic airway inflammation promoted primarily by T-helper type 2 cytokines, the key regulator of eosinophils ...
Allen L. Wolford+3 more
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Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis
New England Journal of MedicineEosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by eosinophilic inflammation. Benralizumab, a monoclonal antibody against the interleukin-5α receptor expressed on eosinophils, may be an option for treating EGPA.We conducted a multicenter, double-blind, phase 3, randomized, active-controlled noninferiority trial to ...
Wechsler, Michael E+18 more
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Hypereosinophilic Syndrome and Mepolizumab
New England Journal of Medicine, 2008Robert M, Boucher+2 more
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Mepolizumab for chronic rhinosinusitis with nasal polyps
The Lancet Respiratory Medicine, 2021Philippe Gevaert, Guy Brusselle
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Severe eosinophilic asthma and mepolizumab
The Lancet Respiratory Medicine, 2016openaire +3 more sources