Results 11 to 20 of about 119 (115)

Osteolathyrogenic Action of Mercaptoethylamine and of Cystamine.

Experimental Biology and Medicine, 1958
SummaryThe osteolathyrogenic action of β-mercaptoethylamine (cysteamine), when fed to rats as the hydrochloride, was confirmed. Cystamine was found to have similar properties. Gross and microscopic skeletal changes were similar to those produced by osteolathyrogenic nitriles.
W, DASLER, R V, MILLISER
openaire   +2 more sources

Protection Against Radiation Lethality: Effect of  -Mercaptoethylamine.

Experimental Biology and Medicine, 1953
Summary and ConclusionsSome 32% of the Swiss albino and 67% of the CF1 male mice injected intraperitoneally with β-mercaptoethylamine (i.e., cysteinamine) prior to a lethal exposure of 700 r whole body x-irradiation survived the 30-day observation period. Some 97% of these are still alive 60 days after irradiation.
R, RUGH, S C, WANG
openaire   +4 more sources

Influence of Hypothermia on the Radioprotective Effects of β-Mercaptoethylamine

Nature, 1964
IN 1951 Bacq et al.1 showed that β-mercaptoethylamine (MEA) could protect mice against ionizing radiation. Essentially, three mechanisms for the protective action of this compound have been considered. They are pictured as scavenging free radicals2,3, lowering the oxygen tension in tissues4,5, or forming complexes with sulphur-containing proteins by ...
R, GERSCHMAN, S W, NYE, D L, GILBERT, P, DWYER, W O, FENN   +4 more
openaire   +4 more sources

Matching TGF‐β1 Activation With Stress‐Responsive Charge‐Reversal Hydrogel Microspheres for the Treatment of Osteoarthritis

Exploration, EarlyView.
Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin, Yiwen Xu, Lei Xiang, Yueliang Zhu, Yihan Li, Yaping Zhuang, Zengjie Zhang, Jiayu Chen, Heemin Kang, Ning Zhang, Xiaohua Yu, Wenguo Cui   +11 more
wiley   +1 more source

Direct Measurement of Protein Corona Thickness on Nanomaterials Using Dual‐Color Stochastic Optical Reconstruction Microscopy (STORM)

Small Methods, EarlyView.
Quantitative dual‐color STORM imaging provides direct nanoscale measurement of protein coronas on nanoparticles in biological media. The approach reveals consistent ∼50 nm corona layers, establishing a reproducible method for characterizing the nanomaterial‐protein interfaces.
Bradley T. Cech, Sophie M. Sullivan, Christopher C. Landry   +2 more
wiley   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Accessing Metal‐Containing Species in Tin–Lead Perovskite Precursor Solutions via Molecular Strategies Guided by the Hard–Soft Acid–Base Principle

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Molecular strategies guided by the hard–soft acid–base (HSAB) principle enable precise control over metal‐based species in perovskite precursor solutions. This approach enhances the quality of narrow‐bandgap (1.26 eV) mixed tin–lead perovskite films and improves the performance of the resulting solar cell devices.
Shuaifeng Hu, Xinru Sun, Wentao Liu, Luca Gregori, Pei Zhao, Jorge Pascual, André Dallmann, Akash Dasgupta, Fengjiu Yang, Guixiang Li, Mahmoud Aldamasy, Silver‐Hamill Turren‐Cruz, Marion A. Flatken, Sheng Fu, Yasuko Iwasaki, Richard Murdey, Armin Hoell, Susan Schorr, Steve Albrecht, Shangfeng Yang, Antonio Abate, Atsushi Wakamiya, Filippo De Angelis, Meng Li, Henry J. Snaith   +24 more
wiley   +2 more sources

Macrophage‐targeted cerium‐tannic acid metal‐polyphenol framework nanoenzyme promotes in situ heart valves regeneration through adaptive immunomodulation

BMEMat, Volume 4, Issue 2, June 2026.
A novel nanoenzyme based on cerium ions‐tannic acid metal‐polyphenol framework (FCT) has been developed and loaded onto DHVs for targeting M1 macrophages to reduce their ROS level and reprogram macrophage phenotype, thereby eliminating inflammation, promoting endothelialization and adaptive matrix remodeling of scaffolds, offering a promising strategy ...
Peng Song, Yunlong Wu, Xing Chen, Yafei Liu, Mengna Dong, Jiawei Shi, Xichi Wang, Nianguo Dong, Weihua Qiao, Qin Wang   +9 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, Volume 13, Issue 30, 28 May 2026.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

MGL‐Based Drug Conjugate: A Novel Glycan‐Targeting Strategy for Potential Precision Cancer Therapy

ChemistryEurope, Volume 4, Issue 5, May 2026.
An engineered macrophage galactose‐type lectin (MGL)‐based conjugate (mMGL‐vcMMAE), incorporating an exposed cysteine for site‐specific drug linkage, preserves stability, binding profile, and affinity of the native MGL carbohydrate recognition domain. It also selectively targets Tn/STn‐expressing cancer cells and shows recognition of colorectal cancer ...
Carlos D. L. Lima, Rafaela Abrantes, Victor Lorrain, Joana Gomes, Reyes Núñez‐Franco, João P. M. António, Catarina Gomes, Ana Gimeno, Benedita A. Pinheiro, Angelina S. Palma, Jesús Jiménez‐Barbero, Pedro M. P. Gois, Gonzalo Jiménez‐Osés, Sandra J. van Vliet, Celso A. Reis, Filipa Marcelo   +15 more
wiley   +1 more source